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Assistant Professor
UAMS College of Medicine
Pathology
UAMS, Little Rock
- Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H & Yeh WC. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446, 203-207 (2007).
- Lu YC, Yeh WC & Ohashi PS. Review Article: LPS/TLR4 signal transduction pathway. Cytokine 42, 145-151 (2008) (>1000 citations).
- Lu YC, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, Gerondakis S, Akira S, Gaffen SL, Yeh WC & Ohashi PS. Differential role for c-Rel and C/EBPb/d in TLR-mediated induction of proinflammatory cytokines. J Immunology 182, 7212-7221 (2009).
- Deenick EK, Po L, Chapatte L, Murakami K, Lu YC, Elford AR, Saibil SD, Ruland JU, Gerondakis S, Mak TW & Ohashi PS. c-Rel phenocopies PKCq but not Bcl-10 in regulating CD8 T cell activation versus tolerance. European J Immunology 40, 867-877 (2010).
- Lin WJ, Su YW, Lu YC, Hao Z, Chio I, Chen NJ, Brüstle A, Li WY & Mak TW. Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFkappaB2 signaling that contributes to autoimmunity. Proceedings of the National Academy of Sciences USA 108, 18354-18359 (2011).
- Yao X, Ahmadzadeh M, Lu YC, Liewehr DJ, Dudley ME, Liu F, Schrump DS, Steinberg SM, Rosenberg SA & Robbins PF. Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood 119, 5688-5696 (2012).
- Lu YC*, Yao X, Li YF, El-Gamil M, Dudley ME, Yang JC, Almeida JR, Douek DC, Samuels Y, Rosenberg SA & Robbins PF*. Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression. J Immunology 190, 6034-6042 (2013).
- Robbins PF, Lu YC, El-Gamil M, Li YF, Gross C, Gartner J, Lin JC, Teer JK, Cliften P, Tycksen E, Samuels Y & Rosenberg SA. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nature Medicine 19, 747-752 (2013).
- Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC & Rosenberg SA. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344, 641-645 (2014).
- Lu YC*, Yao X, Crystal JS, Li YF, El-Gamil M, Gross C, Davis L, Dudley ME, Yang JC, Samuels Y, Rosenberg SA & Robbins PF*. Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clinical Cancer Research 20, 3401-3410 (2014).
- Tran E, Ahmadzadeh M, Lu YC, Gros A, Turcotte S, Robbins PF, Gartner J, Zheng Z, Li YF, Ray S, Wunderlich JR, Somerville RP & Rosenberg SA. Immunogenicity of somatic mutations in human gastrointestinal cancers. Science 350, 1387-1390 (2015).
- Lu YC* & Robbins PF*. Review Article: Cancer immunotherapy targeting neoantigens. Seminars in Immunology 28, 22-27 (2016).
- Yao X**, Lu YC**, Parker LL, Li YF, El-Gamil M, Xu H, van der Bruggen P, Feldman SA, Rosenberg SA & Robbins PF. Isolation and characterization of an HLA-DPB1*04:01-restricted MAGE-A3 T cell receptor for cancer immunotherapy. J Immunotherapy 39, 191-201 (2016). **Co-first authors.
- Lu YC & Robbins PF. Review Article: Targeting neoantigens for cancer immunotherapy. International Immunology 28, 365-370 (2016).
- Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR & Rosenberg SA. T-Cell transfer therapy targeting mutant KRAS in cancer. New England J Medicine 375, 2255-2262 (2016).
- Assadipour Y, Zacharakis N, Crystal JS, Prickett TD, Gartner JJ, Somerville RPT, Xu H, Black MA, Jia L, Chinnasamy H, Kriley I, Lu L, Wunderlich JR, Zheng Z, Lu YC, Robbins PF, Rosenberg SA, Goff SL & Feldman SA. Characterization of an immunogenic mutation in a patient with metastatic triple-negative breast cancer. Clinical Cancer Research 23, 4347-4353 (2017).
- Lu YC, Parker LL, Lu T, Zheng Z, Toomey MA, White DE, Yao X, Li YF, Robbins PF, Feldman SA, van der Bruggen P, Klebanoff CA, Goff SL, Sherry RM, Kammula US, Yang JC & Rosenberg SA. Treatment of patients with metastatic cancer using a major histocompatibility complex class II-restricted T-cell receptor targeting the cancer germline antigen MAGE-A3. Journal of Clinical Oncology 35, 3322-3329 (2017).
- Lu YC*, Zheng Z, Robbins PF, Tran E, Prickett TD, Gartner JJ, Li YF, Ray S, Franco Z, Bliskovsky V, Fitzgerald PC & Rosenberg SA*. An efficient single-cell RNA-seq approach to identify neoantigen-specific T cell receptors. Molecular Therapy 26, 379-389 (2018).
- Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL & Feldman SA. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nature Medicine 24, 724-730 (2018).
- Cafri G, Yossef R, Pasetto A, Deniger DC, Lu YC, Parkhurst M, Gartner JJ, Jia L, Ray S, Ngo LT, Jafferji M, Sachs A, Prickett T, Robbins PF & Rosenberg SA. Memory T Cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients. Nature Communications 10, 449 (2019).
- Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger DC, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS & Rosenberg SA. Immunologic recognition of a shared p53 mutated neoantigen in a patient with metastatic colorectal cancer. Cancer Immunology Research 7, 534-543 (2019).
- Goff SL, Morgan RA, Yang JC, Sherry RM, Robbins PF, Restifo NP, Feldman SA, Lu YC, Lu L, Zheng Z, Xi L, Epstein M, McIntyre LS, Malekzadeh P, Raffeld M, Fine HA & Rosenberg SA. Pilot trial of adoptive transfer of chimeric antigen receptor-transduced T cells targeting EGFRvIII in patients with glioblastoma. J Immunotherapy 42, 126-135 (2019).
- Leko V, McDuffie LA, Zheng Z, Gartner JJ, Prickett T, Apolo AB, Agarwal PK, Rosenberg SA & Lu YC*. Identification of neoantigen-reactive tumor-infiltrating lymphocytes in primary bladder cancer. J Immunology 202, 3458-3467 (2019).
- Lu YC*, Jia L, Zheng Z, Tran E, Robbins PF & Rosenberg SA*. Single-cell transcriptome analysis reveals gene signatures associated with T-cell persistence following adoptive cell therapy. Cancer Immunology Research 7, 1824-1836 (2019).
- Robbins PF, Lu YC. Book Chapter: Immunology of melanoma. In: Balch C. et al. (eds) Cutaneous Melanoma, 6th Edition, Springer, 41-72 (2020).
- Lu YC*, Wang XJ. Editorial: Harnessing the power of the immune system in cancer immunotherapy and cancer prevention. Molecular Carcinogenesis 59, 675-678 (2020). *Corresponding author(s)