My areas of expertise include proteomics, mass spectrometry, histone epigenetics, cancer epigenetics, melanoma cancer biology, melanoma mouse models, and melanoma cell culture models. I hold the Scharlau Family Endowed Chair of Cancer Research, direct the NIH IDeA National Resource for Quantitative Proteomics, and direct a NIH Center of Biomedical Research Excellence in systems biology. My current research interest is to understand why some patients show limited response to immunotherapies and then leveraging this information to design new cancer therapies to help all patients realize the lifesaving benefits of immunotherapy. My work is specifically focused on immunotherapy treatment of patients with metastatic melanoma. Towards these efforts, I lead a translational team of researchers, oncologists, surgeons, and pathologists at the UAMS Winthrop P. Rockefeller Cancer Institute.