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501-686-7958
About
Professor
UAMS College of Medicine
Microbiology and Immunology
UAMS, Little Rock
1. Alkam, D., Wangsurawat, T., Nookaew, I., Richardson, A.R., Ussery, D., Smeltzer, M.S., and Jenjaroenpun, P. Investigating PCR amplification bias in TnSeq using PCR-based and PCR-free transposon sequencing. Microbial Genomics, submitted.
- Albayati, Z., Penthala, N.R., Bommagani, S., Post, G., Smeltzer, M.S., and Crooks, P. Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone. Toxicology Reports, in press.
- Alkam, D., Jenjaroenpunb, P., Ramirez, A.M., Spencer, H.J., and Smeltzer, M.S. 2021. The increased accumulation of Staphylococcus aureus virulence factors is maximized in a purR mutant by the increased production of SarA and decreased production of extracellular proteases, Infection and Immunity, Online ahead of print.
- Harrison, Z.L., Pace, L.R., Brown, M.N., Beenken, K.E., Smeltzer, M.S., Bumgardner, J.D., Haggard, W.O., Amber, Jennings J. 2021. Staphylococcal infection prevention using antibiotic-loaded mannitol-chitosan paste in rabbit model of implant-associated osteomyelitis. Journal of Orthopaedic Research, Online ahead of print.
- Rom, J.S., Beenken, K.E., Ramiriez, A.M., Walker, C.M., Echols, E.J., and Smeltzer, M.S. 2021. Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of Staphylococcus aureus LAC and UAMS-1. Virulence, 12(1):584-600.
- Ramirez, A.M., Beenken, K.E., Bryum, S.D., Tackett, A.J., Shaw, L.N., Gimza, B.D. and Smeltzer, M.S. 2020. SarA plays a predominant role in controlling the production of extracellular proteases in diverse clinical isolates of Staphylococcus aureus. Virulence, 11:1738-1762.
- Ramirez, A.M., Bryrum, S.D., Beenken, K.E., Tackett, A.J., and Smeltzer, M.S. 2020. Exploiting correlations between protein abundance and the functional status of saeRS and sarA to identify virulence factors of potential importance in the pathogenesis of Staphylococcus aureus osteomyelitis. ACS Infectious Disease, 6:237-249. PMCID:PMC7294808.
- Rom, J.S., Ramirez, A.M., Beenken, K.E., Spencer, H.J., Sahukhal, G.S., Elasri, M.O. and Smeltzer, M.S. 2020. Defining the contribution of msaABCR to sarA-associated phenotypes in Staphylococcus aureus. Infection and Immunity, 88:e00530-19. PMCID:PMC6977130.
- Harrington, W.N., Nolan, J.A., Nedosekin, D., Smeltzer, M., Zharov, V.P. 2020. Real-time monitoring of bacteria clearance from blood in a murine model. Cytometry Part A, 97:706-712. PMID:31769208.
- Branna, K.R., Fullerton, M.S., Onyilaghaa, F.I., Princea, A.A., Kurten, R.C., Rom, R.S., Blevins, J.S., Smeltzer, M.S., and Voth, D.E. 2019. Infection of primary human alveolar macrophages alters Staphylococcus aureus toxin production and activity. Infection and Immunity, 87:e00167-19. PMCID: PMC6589068.
- Greene, E., Flees, J., Dhamad, A., Airubaye, A., Hennigan, S., Pleimann, J., Smeltzer, M., Murray, S., Kugel, J., Goodrich, J., Robertson, A., Wideman, R., Rhoads, D., Dridi, S. 2019. Double-stranded RNA is a novel molecular target in osteomyelitis pathogenesis: A translational avian model for human bacterial chondronecrosis with osteomyelitis. American Journal of Pathology. 189:2077-2089. PMID: 31381888.
- Meeker, D.G., Cooper, K.B., Spencer, H.J., Renard, R.L., Mears, S.C., Barnes, C.L., and Smeltzer, M.S. 2019. Comparative study of antibiotic elution profiles from alternative formulations of polymethymethacrylate (PMMA) bone cement. Journal of Arthoplasty, 34:1458-1461. PMID: 30935799.
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- Saeed, K., McLaren, A.C., Schwarz, E.M., Antoci, V., Arnold, W.V., Chen, A.F., Clauss, M., Esteban, J., Gant, V., Hendershot, E., Hickok, N., Higuera, C.A., Coraça-Huber, D.C., Choe, H., Jennings, J.A., Joshi, M., Li, W.T., Noble, P.C., Phillips, K.S., Pottinger, P.S., Restrepo, C., Rohde, H., Schaer, T.P., Shen, H., Smeltzer, M., Stoodley, P., Webb, J.C.J., Witsø, E. 2018. International consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections. Journal of Orthopaedic Research. 37:1007-1017. PMID: 30667567.
- Byrum, S.D., Loughran, A.J., Beenken, K.E., Orr, L.M., Mackintosh, S.G., Edmondson, R.D., Tackett, A.J., and Smeltzer, M.S. 2018. Label-free proteomic approach to characterize protease-dependent and independent effects of sarA inactivation on the Staphylococcus aureus exoproteome. ACS Journal of Proteome Research, 17:3384-3395. PMCID: PMC6209314.
- Zakeyah, A.A., Whitt, J., Duke, C., Gilmore, D.F., Meeker, D.G., Smeltzer, M.S., Alam, M.A. 2018. Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid. Bioorganic & Medicinal Chemistry Letters, 28:2914-2919 PMCID: PMC6137024.
- Blom A, Cho J, Fleischman A, Goswami K, Ketonis C, Kunustor S, Makar G, Meeker DG, Morgan-Jones R, Ortega-Peña S, Parvizi J, Smeltzer M, Stambough JB, Urish K, Tonelo Zilotto GP. 2018. General assembly, prevention, antiseptic irrigation solution: Proceedings of international consensus on orthopedic infections. Journal of Arthoplasty. Epub ahead of print.
- Boles, L.R., Awais, R., Beenken, K.E., Smeltzer, M.S., Haggard, W.O., Jessica, A.J. 2018. Local delivery of amikacin and vancomycin from chitosan sponges prevent polymicrobial implant-associated biofilm. Military Medicine, 83:459-465. PMID: 29635622.
- Wells, C.M., Beenken, K.E., Smeltzer, M.S., Courtney, H.S., Jennings, J.A., Haggard, W.O. 2018. Ciprofloxacin and rifampin dual antibiotic-loaded biopolymer chitosan sponge for bacterial inhibition. Military Medicine, 183:433-444. PMID: 29635619.
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- Chopra, R., Levi-Polyachenko, N., Smeltzer, M.S. 2018. Introduction to the special issue on thermal therapy and infectious diseases. International. Journal of Hyperthermia, 34:133-134. PMID: 29498313
- Meeker, D.G., Wang, T., Harrington, W.N., Zharov, V.P., Johnson, S.A., Jenkins, S.V., Oyibo, S., Walker, C.M., Mills, W.B., Shirtliff, M.E., Beenken, K.E., Chen, J., and Smeltzer, M.S. 2018. Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections. International. Journal of Hyperthermia, 34:209-219. PMCID: PMC6095133.
- Moon, S.E., Zhang, X., Zheng, G., Meeker, D.G., Smeltzer, M.S., and Huang, E. 2017. Novel linear lipopeptide paenipeptins with potential for eradicating biofilms and sensitizing Gram-negative bacteria to rifampicin and clarithromycin. Journal of Medicinal Chemistry, 60:9630-9640.
- Rom, J.S., Atwood, D.N., Beenken, K.E., Meeker, D.G., Loughran, A.J., Spencer, H.J., and Smeltzer, M.S. 2017. Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 LAC on virulence in a murine bacteremia model. Virulence, 8:1776-1790. PMCID: PMC5810510.
- Berretta, J.M., Jennings, J.A., Courtney, H.S., Beenken, K.E., Smeltzer, M.S. and Haggard, W.E. 2017. Blended chitosan paste for infection prevention: Preliminary and preclinical evaluation. Clinical Orthopaedics and Related Research, 475:1857-1870.
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- Harris, M.A., Beenken, K.E., Smeltzer, M.S., Haggard, W.E., and Jennings, J.A. 2017. Phosphotidylcholine coatings deliver local antimicrobials and reduce infection in a murine model: A preliminary study. Clinical Orthopaedics and Related Research, 475:1847-1853. PMCID: PMC5449318.
- Rhodes, C.S., Alexander, C.M., Berretta, J.M., Courtney, H.S., Beenken, K.E., Smeltzer, M.S., Bumgardner, J.D., Haggard, W.O. and Jennings, A. 2017. Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device. World Journal of Orthopaedics, 18:130-141. PMCID: PMC5314142.
- Meeker, D.G., Loughran, A.J., Beenken, K.E., Spencer, H.J., Lynn, W.B., Mills, W.B., and Smeltzer, M.S. 2016. Evaluation of antibiotics effective against methicillin-resistant Staphylococcus aureus based on efficacy in the context of an established biofilm. Antimicrobial Agents and Chemotherapy, 60:5688-5694. PMCID: PMC5038242.
- Meeker, D.G., Chen, J., and Smeltzer, M.S. 2016. Could targeted, antibiotic-loaded gold nanoconstructs provide a new weapon to fight infection? Nanomedicine, 11:2379-2382. PMCID: PMC5561798.
- Smeltzer, M.S. 2016. Staphylococcus aureus pathogenesis: The importance of reduced cytotoxicity. Trends in Microbiology, 24:681-682. PMID: 27450110; PMCID in process.
- Loughran, A.J., Gaddy, D., Beenken, K.E., Meeker, D.G., Morello, R., Zhao, H., Byrum, S.D., Tackett, A.J., Cassat, J.E., and Smeltzer, M.S. 2016. Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infection and Immunity, 84:2586-2594. PMCID: PMC4995912.
- Jennings, J.A., Beenken, K.E., Parker, A.C., Smith, J.K., Courtney, H.S., Smeltzer, M.S., and Haggard, W.O. 2016. Polymicrobial biofilm inhibition effects of acetate-buffered chitosan sponge delivery device. Macromolecular Bioscience. 16:591-598. PMID 26756211.
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- Jennings, J.A., Beenken, K.E., Skinner, R.A., Meeker, D.G., Smeltzer, M.S., Haggard, W.O. and Troxel, K.S. 2016. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World Journal of Orthopaedics, 7:467-474. PMCID: PMC4990767.
- Atwood, D.N., Beenken, K.E., Loughran, A.J., Meeker, D.G., Lantz, T.L., Graham, J.W., Spencer, H.J., and Smeltzer, M.S. 2016. XerC contributes to Staphylococcus aureus biofilm-associated versus acute infections via agr-independent and agr-dependent pathways respectively. Infection and Immunity. 84:1214-1225. PMCID: PMC4807471.
- Meeker, D.G., Jenkins, S.V., Miller, E.K., Beenken, K.E., Loughran, A.J., Powless, A., Muldoon, T.J., Galanzha, E.I., Zharov, V.P., Smeltzer, M.S., Chen, J. (Meeker and Jenkins, co-first authors; Smeltzer and Chen, co-corresponding authors.) 2016. Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted, antibiotic-loaded gold nanoconstructs, ACS Infectious Disease. 2:241–250. PMCID: PMC4945994.
- Atwood, D.N., Beenken, K.E., Lantz, T.L., Meeker, D.G., Lynn, W.B., Mills, W.B., Spencer, H.J., and Smeltzer, M.S. 2016. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrobial Agents and Chemotherapy, 60:1826-182. PMCID: PMC4775981.
- Albayati, Z.A.F., Sunkara, M., Schimdt-Malan, S.M., Karau, M.J., Morris, A.J., Steckelberg, J.M, Patel, R., Breen, P., Smeltzer, M.S., Taylor, K.G., Merten, K.E., Pierce, W.M., and Crooks, P.A. 2015. Use of a novel bone-targeting agent for the enhanced delivery of vancomycin to bone. Antimicrobial Agents and Chemotherapy. 60:1865-1868. PMCID: PMC4776008.
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- Atwood, D.N., Loughran, A.J., Courtney, A.P., Anthony, A.C., Meeker, D.G., Spencer, H.J., Gupta, R.K., Lee, C.Y., Beenken, K.E., Smeltzer, M.S. 2015. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. MicrobiologyOpen. 4:436-451. PMCID: PMC4475386.
- Cue, D., Junecko, J.M., Mei, G., Blevins, J., Smeltzer, M.S., and Lee, C.Y. 2015. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One, 10:e0123027. PMCID:PMC4390220.
- Parker, A.C., Beenken, K.E., Jennings, J.A., Hittle, L., Shirtliff, M.E., Bumgardner, J.D., Smeltzer, M.S. and Haggard, W.O. 2015. Characterization of local delivery with amphotericin B and vancomycin from modified chitosan sponges and functional biofilm prevention evaluation. Journal of Orthopaedic Research, 33:439-447. PMID:25408519.
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- Jennings, J.A., Carpenter, D.P., Troxel, K.S., Beenken, K.E., Smeltzer, M.S., Courtney, H.S., Haggard, W.O. 2015. Novel antibiotic-loaded point-of-care implant coating inhibits biofilm. Clinical Orthopaedics and Related Research. 473:2270-2282. PMCID:PMC4457766.
- Loughran, A.J., Atwood, D.N., Anthony, A.C., Harik, N.S., Spencer, H.J., Beenken, K.E., and Smeltzer, M.S. 2014. Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants. MicrobiologyOpen, 3:897-909. PMCID: PMC4263513.
- Beenken, K.E., Smith, J.K., Skinner, R.A., McLaren, S.G., Bellamy, W., Gruenwald, M.J., Spencer, H.J., Haggard, W.O., and Smeltzer, M.S. 2014. Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis. Journal of Biomaterials Applications, 29:514-523. PMCID: PMC4264383.
- Beenken, K.E., Mrak L.N., Zielinska, A.K., Atwood, D.N., Loughran, A.J., Griffin, L.M., Matthews, K.A., Anthony, A.C., Spencer, H.J., Post, G.R., Lee, C.Y., and Smeltzer, M.S. 2014. Impact of the functional status of saeRS on in vivo phenotypes of sarA mutants in Staphylococcus aureus. Molecular Microbiology, 92:1299-1312. PMCID: PMC4084611.
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- Cassat J.E., Smeltzer M.S., Lee C.Y. 2014. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods in Molecular Biology, 1085:195-211. PMID:24085698.
- Snowden J.N., Beaver M., Beenken K., Smeltzer M., Horswill A.R., Kielian T. 2013. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. PLoS ONE, 8:e84089. PMCID:PMC3875531.
- Nedosekin D.A., Juratli, M.A., Sarimollaoglu, M., Moore, C.L., Rusch, N.L., Smeltzer, M.S., Zharov, V.P. 2013. Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo. Journal of Biophotonics, 6:523-533. PMCID:PMC3954749.
- Cassat, J.E., Hammer, N.D., Campbell, P., Benson, M.A., Perrien, D.S., Mrak, L.N., Smeltzer, M.S., Torres, V.J., Skaar, E.P. 2013. A secreted protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host and Microbe, 13:759-772. PMCID: PMC3721972.
- Hart, M.E., Tsang, L.H., Deck, J., Daily, S.T., Jones, R.C., Liu, H., Hu, H., Hart. M.J., Smeltzer, M.S. 2013. Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr, and sarA agr regulatory mutants. Microbiology. 159:782-791. PMCID:PMC3709827.
- Hobby, G.H., Quave, C.L., Nelson, K., Compadre, C.M., Beenken, K.E., and Smeltzer, M.S., 2012. Quercus cerris extracts limit Staphylococcus aureus biofilm formation. Journal of Ethnopharmacololgy, 144:812-815. PMCID: PMC3516361.
- Zielinska, A.K., Beenken, K.E., Mrak, L.N., Spencer, H.J., Post, G.R., Skinner, R.A., Tackett, A.J., Horswill, A.R., Smeltzer, M.S. 2012. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Molecular Microbiology, 86:1183-1196. PMCID:PMC3508076.
- Galanzha EI, Shashkov E, Sarimollaoglu M, Beenken KE, Basnakian AG, Shirtliff ME, Kim JW, Smeltzer MS, Zharov VP. 2012. in vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles. PLoS One. 7:e45557. PMCID:PMC3458934.
- Beenken, K.E., Bradney, L., Bellamy, W., Skinner, R.A., McLaren, S.G., Gruenwald, M.J., Spencer, H.J., Smith, J.K., Haggard, W.O., Smeltzer. M.S. 2012. Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis. Antimicrobial Agents and Chemotherapy, 56:5839-5844. PMCID:PMC3486578.
- Morrison JM, Anderson KL, Beenken KE, Smeltzer MS, Dunman PM. 2012. The staphylococcal accessory regulator, SarA, is an RNA-binding protein that modulates the mRNA turnover properties of late-exponential and stationary phase Staphylococcus aureus Cells. Frontiers Cell Infection Microbiology. 2:26. PMCID:PMC3417590.
- Snowden, J.N., Beaver, M., Smeltzer, M.S., and Kielian, T. 2012. Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system. Infection and Immunity, 80:3206-3214. PMCID:PMC3418739.
- Brown, T.L.Y., Spencer, H.J., Beenken, K.E., Alpe, T.L., Bartel, T.B., Bellamy, W., Gruenwald, J.M., Skinner, R.A., McLaren, S.G., and Smeltzer, M.S. 2012. Evaluation of [18F]-FDG-PET imaging for the detection of acute post-surgical bone infection. PLoS ONE, 7:e41863. PMCID:PMC3408436.
- Junecko, J., Zielinska, A.K., Mrak, L.N., Ryan, D., Graham, J.W., Smeltzer, M.S., and Lee, C.Y. 2012. Transcribing virulence in Staphylococcus aureus. World Journal of Clinical Infectious Disease. 2:63-76.
- Mrak, L.N., Zielinska, A.K., Beenken, K.E., Mrak, I.N., Atwood, D.N., Griffin, L.M., Lee, C.Y. and Smeltzer, M.S. 2012. saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus. PLoS ONE, 7:e38453. PMCID:PMC3369899.
- Beenken K.E., Spencer H., Griffin L.M., and Smeltzer M.S. 2012. Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions. Infection and Immunity, 80:1634-1638. PMCID:PMC3347440.Kiedrowski, M.R., Kavanaugh, J.S., Malone, C.L., Mootz, J.M., Voyich, J.M., Smeltzer, M.S., Bayles, K.W., Horswill, A.R., 2011. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS ONE, 6:e26714. PMCID:PMC3214024.
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- Quave CL, Estévez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. 2012. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 7:e28737. PMCID:PMC3252291.
- Abel J., Goldmann O., Ziegler C., Höltje C., Smeltzer M.S., Cheung A.L., Bruhn D., Rohde M., Medina E. 2011. Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake. Journal of Innate Immunity, 3:495-501. PMID:21654154.
- Ordonoz, P.E., Quave, C.L., Reynolds, W.F., Varughese, K.I., Berry, B., Malagon, O., Smeltzer, M.S., Compadre, C.M. 2011. Sesquiterpene lactons from Gynoxys verrucosa and their anti-MRSA activity. Journal of Ethnopharmacology, 137:1055-1059. PMCID:PMC3159821.
- Zielinska, A., Beenken, K.E., Joo, H-S., Mrak, L., Griffin, L.M., Luong, T.T., Lee, C.Y., Otto, M., Shaw, L.N., and Smeltzer, M.S. 2011. Defining the strain-dependent impact of the staphylococcal accessory regulator (sarA) on the alpha toxin phenotype of Staphylococcus aureus, Journal of Bacteriology, 193:2948-2958. PMCID:PMC3133183.
- Gurjala, A.N., Geringer, M.R., Seth, A.K., Hong, S.J., Smeltzer, M.S., Galiano, R.D., Leung, K.P. and Mustoe, T.A. 2011. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair and Regeneration, 19:400-410. PMID:21654154.
- Olson, P.D., Kuechenmeister, L.J., Anderson, K.L., Beenken, K.E., Reniere, M.L., Lewis, T.L., Weiss, W.J., Pulse, M., Nguyen, P., Simecka, J.W., Morrison, J.M., Sayood, K., Asojo, O.A., Smeltzer, M.S., Skaar, E.P., and Dunman, P.M. 2011. Small molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA degradation exhibit antimicrobial activity and diminish pathogenesis. PLoS Pathogens, 7:e1001287. PMCID:PMC3037362.
- Smith, J.K., Bumgardner, J.D., Courtney, H.S., Smeltzer, M.S., and Haggard, W.O. 2010. Antibiotic-loaded chitosan film for infection prevention: A preliminary in vitro characterization. Journal of Biomedical Materials, 94:203-211. PMCID:PMC4376318.
- Beenken, K.E., Mrak, L.N., Griffin, L.M., Zielinska, A.K, Shaw, L.N., Rice, K.C., Horswill, A.R., Bayles, K.W., and Smeltzer, M.S. 2010. Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS ONE, 5:e10790. PMCID:PMC2875390.
- Harik, N.S. and Smeltzer, M.S. 2010. Management of osteomyelitis in children. Expert Review of Anti-infective Therapy, 8:175-181. PMCID:PMC2836799.
- Fujimoto, D.F., Higginbotham, R.H., Maleki, S.J., Segall, A.M., Smeltzer, M.S., and Hurlburt, B.K. 2009. Staphylococcus aureus SarA is a regulatory protein responsive to redox and pH that can support bacteriophage lambda integrase-mediated excision/recombination. Molecular Microbiology, 74:1445-1458. PMCID:PMC2879156.
- Weiss, E.C., Zielinska, A., Beenken, K.E., Spencer, H.J., Daily, S.J. and Smeltzer, M.S. 2009. Impact of sarA on daptomycin susceptibility of Staphylococcus aureus biofilms in vivo. Antimicrobial Agents and Chemotherapy, 53:4096-4102. PMCID: PMC2764180.
- Mann, E., Rice, K., Boles, B., Endres, J., Ranjit, D., Chandramohan, L., Tsang, L., Smeltzer, M.S., Horswill, A. and Bayles, K. 2009. Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. PLoS ONE, 4:e5822. PMCID:PMC2688759.
- Nagarajan, V., Smeltzer, M.S., and Elasri, M.O. 2009, Genome-scale transcriptional profiling in Staphylococcus aureus: Bringing order out of chaos. FEMS Microbiology Letters, 295:204-2010. PMCID: PMC2753426.
- Weiss, E.C., Spencer, H.J., Daily, S.J., Weiss, B.D, and Smeltzer, M.S. 2009. Impact of sarA on the antibiotic susceptibility of Staphylococcus aureus in vitro in a catheter-associated biofilm model. Antimicrobial Agents and Chemotherapy, 53:2475-2482. PMCID:PMC2764180.
- Weiss, B.D., Weiss, E.C., Haggard, W.O., McLaren, S.G. and Smeltzer, M.S. 2009. Optimized elution of daptomycin from polymethymethacrylate (PMMA) beads. Antimicrobial Agents and Chemotherapy, 53:264-266. PMCID:PMC2612151.
- Tsang, L.H., Cassat, J.E., Shaw, L.N., Beenken, K.E. and Smeltzer, M.S. 2008. Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants. PLoS ONE, 3:e3361. PMCID: PMC2556392.
- Cassat, J.E., Lee, C.Y., and Smeltzer, M.S. 2007. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol. Biol., 391:127-144. PMCID:PMC4098860.
- Rice, K.C., Mann, E.E., Endres, J.L., Weiss, E.C., Cassat, J.E., Smeltzer, M.S., and Bayles, K.W. 2007. The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proceeding of the National Academy of Sciences (PNAS), 104:8113-8118. PMCID: PMC1876580.
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- Zhu, Y., Weiss, E.C., Otto, M., Fey, P.D., Smeltzer, M.S., and Somerville, G.A. 2007. S. aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis. Infection and Immunity, 75:4219-4226. PMCID: PMC1951195.
- Tsang, L.H., Daily, S., Weiss, E.C., and Smeltzer, M.S. 2007. Mutation of traP in clinical isolates of Staphylococcus aureus has not impact on expression of agr on biofilm formation. Infection and Immunity, 75:4528-4533. PMCID: PMC1951201.
- Roberts, C., Anderson, K.L., Murphy, E., Projan, S.J., Mounts, W., Hurlburt, B., Smeltzer, M., Overbeek, R., Disz, T. and Dunman, P.M. 2006. Characterizing the effect of the Staphylococcus aureus virulence factor regulator SarA on log-phase mRNA half-lives. Journal of Bacteriology, 188:2593-2603. PMCID: PMC1428411.
- Kanangat, S., Postlehwaite, A., Hasty, K., Kang, A., Smeltzer, M., Appling, W. and Schaberg, D. 2006. Induction of multiple matrix metalloproteinases in human dermal and synovia fibroblasts by Staphylococcus aureus: Implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Research and Therapy, 8:R176. PMCID: PMC1794521.
- McLaren, A.C., McLaren, S.G, and Smeltzer, M.S., 2006. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clinical Orthopaedics and Related Research, 451:25-28. PMID:16906079.
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- Sambanthamoorthy, K., Smeltzer, M.S. and Elasri, M.O. 2006. Identification and characterization of msa (SA1233), a gene that is involved in expression of sarA and several virulence factors in Staphylococcus aureus. Microbiology, 152:2559-2572. PMID:16946251.
- Cassat, J.E., Dunman, P.M., Murphy, E.J., Projan, S.J., Beenken, K.E., Palm, K.J., Yang, S-J., Rice, K.C., Bayles, K.W. and Smeltzer, M.S. 2006. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences by comparison to the laboratory strain RN6390. Microbiology, 152:3075-3090. PMID:17005987.
- Zharov, V.P., Mercer, K.E., Galitovskaya, E.N. and Smeltzer, M.S., 2006. Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophysical Journal, 90:619-627. PMCID: PMC1367066.
- Jones-Jackson, L., Walker, R., Purnell, G., McLaren, S.G., Skinner, R.A., Thomas, J.R., Suva, L., Anaissie, E., Miceli, M., Nelson, C.L., Ferris, E. and Smeltzer, M.S. 2005. Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. Journal of Orthopaedic Research, 23:1484-1489. PMID:15896941.
- Nelson, C.L., McLaren, A.C., McLaren, S.G., Johnson, J.W. and Smeltzer, M.S., 2005. Is aseptic loosening really aseptic? Clinical Orthopaedics and Related Research, 437:25-30. PMID:16056022.
- Cassat J.E., Dunman, P.M., McAleese, F., Murphy, E., Projan, S.J. and Smeltzer, M.S., 2005. Comparative genomics of Staphylococcus aureus musculoskeletal isolates. Journal of Bacteriology, 187:547-592. PMCID:PMC543526.
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- Koenig, R.L., Ray, J.L., Maleki, S.J., Smeltzer, M.S. and Hurlburt, B.K., 2004. Staphylococcus aureus AgrA binding to the RNAIII‑agr regulatory region. Journal of Bacteriology, 186:7549-7555. PMCID: PMC524880.
- Beenken, K.E. Dunman, P.M., McAleese, F., Macapagal, D., Murphy, E., Projan, S.J., Blevins, J.S. Smeltzer, M.S., 2004. Global gene expression in Staphylococcus aureus biofilms, Journal of Bacteriology, 186:4665-4684. PMCID: PMC438561.
- O’Leary, J.O., Langevin, M.J., Price, C.T.D., Blevins, J.S., Smeltzer, M.S. and Gustafson, J.E. 2004. Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus. FEMS Microbiology Letters, 237:297-302. PMID:15321676.
- Beenken, K.E., Blevins, J.S. and Smeltzer, M.S. 2003. Mutation of sarA impairs biofilm formation in Staphylococcus aureus. Infection and Immunity, 71:4206-4211. PMCID:PMC161964.
- Sterba, K.M., Mackintosh, S.G., Blevins, J.S., Hurlburt, B.K. and Smeltzer, M.S. 2003. Characterization of Staphylococcus aureus SarA binding sites. Journal of Bacteriology, 185:4410-4417.
- Blevins, J.S., Elasri, M.O., Skinner, R.A., Thomas, J.R. and Smeltzer, M.S. 2003. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infection and Immunity, 71:516-523.
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- Nugyen, L.L., Nelson, C.L., Saccente, M., Smeltzer, M.S., Wassell, D.L. and McLaren, S.G. 2002. Detecting bacterial colonization of implanted orthopaedic devices by ultrasonication. Clinical Orthopaedics and Related Research, 403:29-37.
- Nelson, C.L., McLaren, S.G., Skinner, R.A., Smeltzer, M.S., Thomas, J.R. and Olsen, K.M., 2002. Treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. Journal of Orthopaedic Research, 20:643-647.
- Blevins, J.S., Beenkeen, K.E., Elasri, M.O., Hurlburt, B.K. and Smeltzer, M.S. 2002. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infection and Immunity, 70:470-480.
- Elasri, M. O., Thomas, J.R., Skinner, R.A., Blevins, J.S., Beenken, K.E., Nelson, C.L. and Smeltzer, M.S. 2002. Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis. Bone, 30:275-280.
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- Mason, W.J., Blevins, J.S., Beenken, K.E., Wibowo, N., Ojha, N. and Smeltzer, M.S. 2001. Multiplex PCR protocol for the diagnosis of staphylococcal infection. Journal of Clinical Microbiology, 39:3332-3338.
- Smeltzer, M.S and Gillaspy, A.F. 2000. Molecular pathogenesis of staphylococcal osteomyelitis. Poultry Science, 79:1042-1049.
- Snodgrass, J.L., Mohammed, N., Ross, J.M., Sau, S., Lee, C.Y. and Smeltzer, M.S. 1999. Functional characterization of the Staphylococcus aureus collagen adhesin B domain. Infection and Immunity, 67:3952-3959.
- Ellington, J.K., Reilly, S.S., Warner, K.R., Ramp, W.K., Smeltzer, M.S., Kellam, J.F. and Hudson, M.C. 1999. Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts. Microbial Pathogenesis. 26:317-323.
- Blevins, J.S., Gillaspy, A.F., Rechtin, T.M., Hurlburt, B.K. and Smeltzer, M.S. 1999. The staphylococcal accessory regulator (sar) controls expression of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner. Molecular Microbiology. 33:317-326.
- Rechtin, T.M., Gillaspy, A.F., Schumacher, M., Brennan, R.G., Smeltzer, M.S. and Hurlburt, B.K. 1999. Characterization of SarA virulence gene regulator of Staphylococcus aureus. Molecular Microbiology. 33:307-316.
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- Marcos, J.Y., Soriano, A.C., Salazar, M.S., Moral, C.H., Ramos, S.S., Smeltzer, M.S. and Carrasco, G.N. 1999. Rapid identification and typing of Staphylococcus aureus by PCR-restriction fragment length polymorphism analysis of the aroA gene. Journal of Clinical Microbiology. 37:570-574.
- Gillaspy, A.F., Lee. C.Y., Sau, S., Cheung, A.L. and Smeltzer, M.S. 1998. Factors affecting the collagen binding capacity of Staphylococcus aureus. Infection and Immunity. 66:3170-3178.
- Smeltzer, M.S., Gillaspy, A.F., Pratt, F.L., Jr. and Thames, M.D. 1997. Comparative evaluation of cna, fnbA, fnbB and hlb genomic fingerprinting for the epidemiological typing of Staphylococcus aureus. Journal of Clinical Microbiology. 35:2444-2449.
- Smeltzer, M.S., Gillaspy, A.F., Pratt, F.L. and Iandolo, J.J. 1997. Prevalence and chromosomal map location of Staphylococcus aureus adhesin genes. Gene. 196:249-259.
- Gillaspy, A.F., Patti, J.M., Pratt, F.L., Jr., and Smeltzer, M.S. 1997. The Staphylococcus aureus collagen adhesin-encoding gene (cna) is within a discrete genetic element. Gene. 196:239-248.
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- Smeltzer, M.S., Thomas, J.R., Hickmon, S.G., Skinner, R.A., Nelson, C.L., Griffith, D., Parr, T.R., Jr. and Evans, R.P. 1997. Characterization of a rabbit model of staphylococcal osteomyelitis. Journal of Orthopaedic Research, 15:414-421.
- Gillaspy, A.F., Patti, J.M., Pratt, F.L., Jr., and Smeltzer, M.S. 1997. Transcriptional regulation of the Staphylococcus aureus collagen adhesin gene (cna). Infection and Immunity, 65:1536-1540.
- Smeltzer, M.S., Pratt, F.L., Jr., Gillaspy, A.F. and Young, L.A. 1996. Genomic fingerprinting for the epidemiological differentiation of Staphylococcus aureus clinical isolates. Journal of Clinical Microbiology, 34:1364-1372.
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- Gillaspy, A.F., Hickmon, S.G., Skinner, R.A., Thomas, J.R., Nelson, C.L. and Smeltzer, M.S. 1995. Role of the accessory gene regulator (agr) in the pathogenesis of staphylococcal osteomyelitis. Infection and Immunity, 63:3373-3380.
- Smeltzer, M.S., Hart, M.E. and Iandolo, J.J. 1994. The effect of lysogeny on the genomic organization of Staphylococcus aureus. Gene, 138:51-57.
- Chapes, S.K., Beharka, A.A., Hart, M.E., Smeltzer, M.S. and Iandolo, J.J. 1994. Differential RNA regulation by staphylococcal enterotoxins A and B in murine macrophages. Journal of Leukocyte Biology, 55:533-529.
- Smeltzer, M.S., Hart, M.E. and Iandolo, J.J. 1993. Phenotypic characterization of xpr, a global regulator of extracellular virulence factors in Staphylococcus aureus. Infection and Immunity, 61:919-925.
- Hart, M.E., Smeltzer, M.S. and Iandolo, J.J. 1993. The extracellular protein regulator (xpr) affects exoprotein and agr mRNA levels in Staphylococcus aureus. Infection and Immunity, 175:7895-7879.
- Smeltzer, M.S., Gill, S.R. and Iandolo, J.J. 1992. Localization of a chromosomal mutation affecting expression of extracellular lipase in Staphylococcus aureus. Journal of Bacteriology, 174:4000-4006.
- Smeltzer, M.S., Hart, M.E. and Iandolo, J.J. 1992. Quantitative spectrophotometric assay for lipase activity in Staphylococcus aureus. Applied and Environmental Microbiology, 58:2815-2819.
- Rahaley, R.S., Dennis, S.M., and Smeltzer, M.S. 1983. Comparison of the enzyme-linked immunosorbent assay and complement fixation test for detecting Brucella ovis antibodies in sheep. Veterinary Record, 113:467-470.