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Assistant Professor
UAMS College of Medicine
Pediatrics
ACRI
- Rose S., Melnyk S., Savenka A., Hubanks A., Jernigan S., Cleves M.A., and James S.J. The frequency of polymorphisms affecting lead and mercury toxicity among children with autism. American Journal of Biochemistry and Biotechnology, 2008, 4(2):85-94. DOI: 10.3844/ajbbsp.2008.85.9
- James S.J., Melnyk S., Jernigan S., Hubanks A., Rose S. and Gaylor D.W. Abnormal Transmethylation/ transsulfuration Metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord. 2008 Nov; 38(10):1976. DOI: 10.1007/s10803-008-0614-2
- James S. J., Rose S., Melnyk S., Jernigan S., Blossom S., Pavliv O. and Gaylor D. W. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J., 2009 Aug. 23(8):2374-8. DOI: 10.1096/fj.08-128926
- Melnyk S., Fuchs G.J., Schulz E., Lopez M., Kahler S.G., Fussell J.J., Bellando J., Pavliv O., Rose S., Seidel L., Gaylor D.W. and James S.J. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J. Autism Dev Disord. 2012 Mar. 42(3):367-77. DOI: 10.1007/s10803-011-1260-7
- Rose S., Melnyk S., Trusty T.A., Pavliv O., Seidel L., Li J., Nick T.G., James, S.J. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Research and Treatment. 2012. DOI: 10.1155/2012/986519
- Rose S., Melnyk S., Pavliv O., Bai S., Nick T. G., Frye R. E., James S. J. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry 2:e134. 2012 Jul 10. DOI: 10.1038/tp.2012.61
- Rose S., Frye R.E., Slattery J., Wynne R., Tippett M., Melnyk S., James S.J. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. Transl Psychiatry 4:e3777. 2014 Apr 1 DOI: 10.1038/tp.2014.15
- Rose S., Frye R.E., Slattery J., Wynne R., Tippett M., Pavliv O., Melnyk S. and James S.J. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLOS ONE. 9(1):e85436. 2014 Jan 8. DOI: 10.1371/journal.pone.0085436
- Rose S., Wynne R., Frye R.E., Slattery J., Melnyk S. and James S.J. Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. J.Toxicol. 2015. DOI: /10.1155/2015/573701
- Frye R.E., Rose S., Slattery J., MacFabe D.F. Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microb Ecol Health Dis. 2015 May 7; 26; DOI: 10.3402/mehd.v26.27458
- Frye RE, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Blocking and binding folate receptor alpha autoantibodies identify novel autism spectrum disorder subgroups. Front Neurosci. 2016 Mar 9; DOI: 10.3389/fnins.2016.00080
- Chen J., Lazarenko O., Blackburn M., Rose S., Frye R. E., Andres A., Badger T., Shankar K. Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human. Endocrinology. 2016 Nov; 157(11):4172-4183. DOI: 10.1210/en.2016-1408
- Frye R. E., Rose S, Chacko J, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. Transl Psychiatry. 2016 Oct 25; 6(10):e927. doi: 10.1038/tp.2016.189
- Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB. 2017 Mar; 31(3):904-909. doi: 10.1096/fj.201601004R
- Delhey L, Kilinc EN, Yin, L, Slattery J, Tippett M, Rose S, Bennuri SC, Kahler S, Damle S, Legido A, Goldenthal MJ, Frye RE. The effect of mitochondrial supplements on mitochondrial activity in children with autism spectrum disorder. J. Clin. Med. 2017 Feb 13; 5(2). doi: 10.3390/jcm6020018
- Frye RE, Wynne R, Rose S, Slattery J, Delhey L, Tippett M, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor alpha autoimmune disorder. J. Neuroendocrinol. 2017 Mar; 29(3). doi: 10.1111/jne.12461
- Delhey L, Kilinc EN, Yin, L, Slattery J, Tippett M, Wynne R, Rose S, Kahler S, Damle S, Legido A, Goldenthal MJ, Frye RE. Bioenergetic variation is related to autism symptomatology. Metabolic Brain Disease. 2017 Dec; 32(6):2021-203. DOI: 10.1007/s11011-017-0087-0
- Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Oxidative stress challenge uncovers trichloroacetaldehyde hydrate-induced mitoplasticity in autistic and control lymphoblastoid cell lines. Sci Rep. 2017 Jun 30;7(1):4478. doi: 10.1038/s41598-017-04821-3
- Rose S., Bennuri S.C., Murray K. F., Buie T., Winter H., Frye R.E., Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One 2017 Oct 13; 12(10):e0186377. doi: 10.1371/journal.pone.0186377
- Frye R. E., Nankova B., Bhattacharyya S., Rose S., Bennuri S. C., MacFabe D. F. Modulation of immunological pathways in autistic and neurotypical lymphoblastoid cell lines by the enteric microbiome metabolite propionic acid. Frontiers in Immunology. 2017 Dec 22: 8:1670. doi: 10.3389/fimmu.2017.01670
- Burger B.J., Rose S., Bennuri S.C., Gill P.S., Tippett M.L., Delhey L, Melnyk S., Frye R.E. Autistic siblings with novel mutations in two different genes: Insight for genetic workups of autistic siblings and connection to mitochondrial dysfunction. Front Pediatr. 2017 Oct 12: 5:219. doi: 10.3389/fped.2017.00219
- Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, James SJ, Sequeira JM, Quadros EF. Folinic acid improves verbal communication in children with autism and language impairment: A randomized double-blind placebo controlled trial. Mol Psychiatry. 2018 Feb; 23(2):247-256. doi: 1038/mp.2016.168
- Rose S., Bennuri S.C., Davis J., Wynne R., Slattery J., Tippett M., Delhey L., Melnyk S., Kahler S.G., MacFabe D.F., Frye R.E. Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism. Transl Psychiatry. 2018 Feb 2;8(1):42. doi: 10.1038/s41398-017-0089-z
- Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE. Comparison of treatment for metabolic disorders associated with autism: Reanalysis of three clinical trials. Front Neurosci. 2018 February 12; 12:19. doi: 10.3389/fnins.2018.00019
- Howsman D., Vargason T., Ruben R., Delhey L., Tippett M., Rose S., Bennuri S.C., Slattery J., Melnyk S., James S.J., Frye R.E., Hahn J. Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study. Bioengineering & Translational Medicine. 2018 May 14; 3(2):156-165. DOI: 10.1002/btm2.10095
- Rose S., Niyazov D.M., Rossignol D., Goldenthal M., Kahler S.G., Frye R.E. Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder. Molecular Diagnosis & Therapy. 2018 July 23. DOI: 10.1007/s40291-018-0352-x
- Connery K., Tippett M., Delhey L., Rose S., Slattery J., Kahler S.G., Hahn J., Kruger U., Cunningham M.W., Shimasaki C., Frye R.E. Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism. Transl. Psychiatry. 2018 Aug 10;8(1):148. doi: 10.1038/s41398-018-0214-7
- Vargason T., Kruger U., Roth E., Delhey L.M., Tippett M., Rose S., Bennuri S.C., Slattery J.C., Melnyk S., James S.J., Frye R.E., Hahn J. Comparison of three clinical trial treatments for autism spectrum disorder through multivariate analysis of changes in metabolic profiles and adaptive behavior. Front Cell Neuroscience. 2018 Dec 19; 2:503. doi: 10.3389/fncel.2018.00503
- Jyonouchi H., Geng L., Rose S., Bennuri S.C., Frye R.E. Variations in mitochondrial respiration differ in IL-1β/IL-10 ratio based subgroups in autism spectrum disorders. Frontiers in Psychiatry, 2019 Feb 20, doi: 10.3389/fpsyt.2019.00071
- Bennuri S.C., Rose S., Frye R.E. Mitochondrial dysfunction is inducible in lymphoblastoid cell lines from children with autism and may involve the TORC1 pathway. Frontiers in Psychiatry, 2019 May 07; doi: 10.3389/fpsyt.2019.00269
- Rose S.*, Carvalho E.*, Diaz E.C., Cotter M., Bennuri S.C., Azhar G., Frye R.E., Adams S.H., Borsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab. 2019 Sep; 317(3):E503-E512. DOI: 10.1152/ajpendo.00084.2019.
*co-first authors
- Jyonouchi H., Geng L., Toruner G.A., Rose S., Bennuri S.C., Frye R.E. Serum microRNAs in ASD: association with monocyte cytokine profiles and mitochondrial respiration. Frontiers in Psychiatry, 2019 Sep 10; doi: 10.3389/fpsyt.2019.00614
- Harville T., Rhodes-Clark B., Bennuri S.C., Delhey L., Slattery J., Tippett M., Wynne R., Rose S., Kahler S.G., Frye R.E. Inheritance of HLA-Cw7 associated with autism spectrum disorder (ASD). Frontiers in Psychiatry, 2019 Sep 10; doi: 10.3389/fpsyt.2019.00612.
- Voinsky I., Bennuri S.C., Svigals J., Hadar A., Werner H., Frye R.E.*, Rose, S.*, Gurwitiz, D.* Peripheral blood mononuclear cell oxytocin and vasopressin receptor expression positively correlates with social and behavioral function in children with autism. Sci Rep, 2019 Sep; 9(1):13443. doi: 10.1038/s41598-019-49617-9.
*co-senior authors
- Frye, R.E., Cakir, J., Rose, S., Delhey, L., Bennuri, S.C., Tippett, M., Palmer, R., Austin, C., Curtin, P., Arora, M. Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder. Psychiatry. 2020 July 7. 10, 223 (2020). doi: 10.1038/s41398-020-00905-3
- Frye, R.E., Cakir, J., Rose, S., Delhey, L., Bennuri, S.C., Tippett, M., Melnyk, S., James, S.J., Palmer, R., Austin, C., Curtin, P., Arora, M. Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology. Mol Psychiatry. 2020 Sep 22. https://doi.org/10.1038/s41380-020-00885-2
- Hakkak, R., Rose, S., Spray, B., Kozaczek, M., Korourian, S. Effects of obesity and 10 weeks of metformin treatment on liver steatosis. Biomedical Reports. In Press