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Assistant Professor of Medicine
UAMS College of Medicine
Internal Medicine
UAMS, Little Rock
Total 66 publications, with 28 of them as the first author or corresponding author.
2021
- Li X, Brickell A, Wang X, Zhou S, Ding Z*. NADPH oxidase promotes PCSK9 secretion in macrophages. J Mol Cell Cardiol. 2021, 153:42-43.
- Kore RA, Wang X, Ding Z, Griffin RJ, Tackett AJ, Mehta JL. MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas. Mol Cell Biochem. 2021 Jan 10. doi: 10.1007/s11010-020-04029-6.
2020
- Wang X, Li X, Liu S, Brickell A, Zhang J, Wu Z, Zhou S, Ding Z*. PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Res Cardiol. 2020, 115:66.
- Liu S, Deng X, Zhang P, Wang X, Fan Y, Zhou S, Mu S, Mehta JL, Ding Z*. Blood flow patterns regulate PCSK9 secretion via MyD88 mediated proinflammatory cytokines. Cardiovasc Res. 2020; 116:1721-32.
- Ding Z*, Wang X, Liu S, Zhou S, Kore R, Mu S, Deng X, Fan Y, Mehta JL. NLRP3 inflammasome via IL-1β regulates PCSK9 secretion. Theranostics. 2020, 10:7100-7110. PMID: 32641981 PMCID: PMC7330863
- Ding Z*, Pothineni NVK, Goel A, Lüscher TF, Mehta JL. PCSK9 and inflammation: Role of shear stress, pro-inflammatory cytokines and LOX-1. Cardiovasc Res. 2020;116:908-915.
2019
- Saad M, Salehi N, Ding Z, Mehta JL. Blood pressure target in diabetics: how low is too low? Eur Heart J. 2019, 40:2044-2046.
- Kore RA, Henson JC, Hamzah RN, Griffin RJ, Tackett AJ, Ding Z, Mehta JL. Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes. Sci Rep. 2019;9:19276.
2018
- Ding Z*, Wang X, Liu S, Shahanawaz J, Theus S, Fan Y, Deng X, Zhou S, Mehta JL. PCSK9 expression in the ischemic heart and its relationship to infarct size, cardiac function and development of autophagy. Cardiovasc Res. 2018;114:1738-1751.
- Ding Z*, Liu S, Wang X, Theus S, Deng X, Fan Y, Zhou S, Mehta JL. PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages. Cardiovasc Res. 2018;114:1145-1153.
- Wang X, Guo Z, Ding Z, Mehta JL. Inflammation, Autophagy, and apoptosis after myocardial infarction. J Am Heart Assoc. 2018; 7(9).
2017
- Pothineni NVK, Karathanasis SK, Ding Z, Arulandu A, Varughese KI, Mehta JL. LOX-1 in Atherosclerosis and Myocardial Ischemia: Biology, Genetics, and Modulation. J Am Coll Cardiol. 2017;69:2759-2768.
- Ayoub KF, Pothineni NVK, Rutland J, Ding Z, Mehta JL. Immunity, Inflammation, and Oxidative Stress in Heart Failure: Emerging Molecular Targets. Cardiovasc Drugs Ther. 2017;31:593-608.
2016
- Ding Z, Liu S, Wang X, Mathur P, Dai Y, Theus S, Deng X, Fan Y, Mehta JL. Cross-talk between PCSK9 and damaged mtDNA in vascular smooth muscle cells: role in apoptosis. Antioxid Redox Signal. 2016, 25:997-1008.
- Ding Z, Saldeen TGP, Mathur, Mehta JL. Mixed tocopherols are better than alpha-tocopherol as anti-oxidants as good as statins. Current Research: Cardiology, 2016, 3 (4).
- Cariou B, Ding Z, Mehta JL. PCSK9 and atherosclerosis: Beyond LDL-cholesterol lowering. Atherosclerosis. 2016, 253:275-277. Invited Editorial
- Wang X, Ding Z, Yang F, Dai Y, Chen P, Theus S, Singh S, Budhiraja M, Mehta JL. Modulation of Myocardial Injury and Collagen Deposition Following Ischemia/Reperfusion by Linagliptin, Liraglutide, and Both Together. Clin Sci (Lond). 2016, 130:1353-62.
- Klionsky DJ, Abdelmohsen K, Abe A….Ding Z…. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12:1-222.
- Pothineni NV, Watts TE, Ding Z, Dai Y, Deshmukh AJ. Eptifibatide-Induced Thrombocytopenia--When Inhibitor Turns Killer. Am J Ther. 2016, 23:e298-9.
- Wang XW, Zhang FX, Yang F, Ding Z, Agarwal N, Guo ZK, Mehta JL. Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro. Acta Pharmacol Sin. 2016, 37: 1349-1358. PMID: 27498780.
2015
- Ding Z, Liu S, Wang X, Dai Y, Deng X, Fan Y, Sun C, Wang Y, Mehta JL. Hemodynamic shear stress via ROS modulates PCSK9 expression in human vascular endothelial and smooth muscle cells and along the mouse aorta. Antioxid Redox Signal. 2015, 22:760-771.
- Ding Z, Liu S, Wang X, Deng X, Fan Y, Shahanawaz J, Shmookler Reis R, Varughese KI, Sawamura T, Mehta JL. Cross-talk between LOX-1 and PCSK9 in vascular tissues. Cardiovasc Res. 2015, 107:556-67.
- Ding Z, Liu S, Deng X, Fan Y, Wang X, Mehta JL. Hemodynamic shear stress modulates endothelial cell autophagy: role of LOX-1. Int J Cardiol. 2015, 184C:86-95.
- Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Dai Y, Deng X, Fan Y,Xiang David, Mehta JL. Lectin-like ox-LDL receptor-1 (LOX-1) - Toll-like receptor 4 (TLR4) Interaction and Autophagy in CATH.a Differentiated Cells Exposed to Angiotensin II. Mol Neurobiol. 2015, 51:623-32.
- Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Fan Y, Deng X, Xiang David, Mehta JL. Lectin-like oxidized low-density lipoprotein receptor-1 regulates autophagy and Toll-like receptor 4 in the brain of hypertensive mice. J Hypertens. 2015, 33:525-33.
- Wang X, Ding Z, Lin J, Guo Z, Mehta JL. LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains. Biochem Biophys Res Commun. 2015,467:135-9
- Mathur P, Ding Z, Saldeen T, Mehta JL. Tocopherols in the Prevention and Treatment of Atherosclerosis and Related Cardiovascular Disease. Clin Cardiol. 2015, 38:570-6.
- Wang X, Guo Z, Ding Z, Khaidakov M, Lin J, Xu Z, Sharma SG, Jiwani S, Mehta JL. Endothelin-1 upregulation mediates aging-related cardiac fibrosis. J Mol Cell Cardiol. 2015, 80C:101-109.
2014
- Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Deng X, Fan Y, Xiang David, Mehta JL. LOX-1, mtDNA damage and NLRP3 inflammasome activation in macrophages: implications in atherogenesis. Cardiovasc Res. 2014, 103:619-28.
- Editorial: Christ A, Latz E. LOX-1 and mitochondria: an inflammatory relationship. Cardiovasc Res. 2014;103:435-7
- Mehta JL, Ding Z*,, Liu S, Wang X, Dai Y, Khaidakov M. Hypertension, TLR4 activation in brain and cardiac hypertrophy. Cardiovasc Res. 2014, 103:3-4. Invited Editorial
- Ding Z, Liu S, Wang X, Theus S, Fan Y, Deng X, Mehta JL. LOX-1 - dependent mitochondrial DNA damage and NLRP3 activation during systemic inflammation in mice. Biochem Biophys Res Commun. 2014, 451:637-43.
- Ding Z*,, Liu S, Wang X, Dai Y, Khaidakov M, Mehta JL. LOX-1, mtDNA damage, autophagy and immune response in atherosclerosis. Can J Physiol Pharm. 2014, 92:524-30.
- Khaidakov M, Mercanti F, Wang X, Ding Z, Dai Y, Romeo F, Sawamura T, Mehta JL. Prevention of export of anoxia/reoxygenation injury from ischemic to non-ischemic cardiomyocytes via inhibition of endocytosis. Am J Physiol Heart Circ Physiol. 2014, 306:H1700-7.
- Dai Y, Dai D, Wang X, Ding Z, Li C, Mehta JL. GLP-1 Agonists Inhibit Ox-LDL Uptake in Macrophages by Activating Protein Kinase A. J Cardiovasc Pharmacol. 2014, 64:47-52
- Wang X, Khaidakov M, Guo Z, Ding Z, He Q, Mehta JL. LOX-1 Deletion Limits Cardiac Angiogenesis in Mice Given Angiotensin II. Cardiovasc Drugs Ther. 2014, 28:441-6.
- Dai Y, Dai D, Wang X, Ding Z, Mehta JL. DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway. Cardiovasc Drugs Ther. 2014, 28:425-32.
2013
- Ding Z, Wang X, Schnackenberg L, Khaidakov M, Liu S, Singla S, Dai Y, Mehta JL. Regulation of autophagy and apoptosis in response to oxLDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g. Int J Cardiol. 2013, 168:1378-85.
- Ding Z, Liu S, Sun C, Chen Z, Fan Y, Deng X, Wang X, Mehta JL. Concentration polarization of ox-LDL activates autophagy and apoptosis via regulating LOX-1expression. Sci Rep. 2013, 3:2091.
- Ding Z, Liu S, Wang X, Khaidakov M, Dai Y, Mehta JL. Role of oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis. Sci Rep. 2013, 3:1077.
- Ding Z*, Mizeracki AM, Hu C, Mehta JL. LOX-1 Deletion and Macrophage Trafficking in Atherosclerosis. Biochem Biophys Res Commun. 2013,440:210-4.
- Dai Y, Dai D, Mercanti F, Ding Z, Wang X, Mehta JL. Dipeptidyl peptidase-4 inhibitors in cardioprotection: a promising therapeutic approach. Acta Diabetol. 2013, 50:827-35.
- Dai Y, Mercanti F, Dai D, Wang X, Ding Z, Pothineni NV, Mehta JL. LOX-1, a bridge between GLP-1R and mitochondrial ROS generation in human vascular smooth muscle cells. Biochem Biophys Res Commun. 2013, 437:62-6.
- Wang X, Khaidakov M, Ding Z, Dai Y, Mercanti F, Mehta JL. LOX-1 in the maintenance of cytoskeleton and proliferation in senescent cardiac fibroblasts. J Mol Cell Cardiol. 2013, 60:184-90.
- Wang X, Khaidakov M, Ding Z, Mitra S, Lu J, Liu S, Mehta JL. Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA. Exp Biol Med. 2012, 37:1394-401.
- Dai Y, Wang X, Khaidakov M, Ding Z, Su W, Price E, Palade P, Chen M, Mehta JL. MicroRNAs involved in the regulation of post-ischemic cardiac fibrosis. Hypertension. 2013, 61:751-6.
- Dai Y, Su W, Ding Z, Wang X, Palade P, Chen M, Raina S, Mehta JL. Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-<gamma>. Biochem Biophys Res Commun. 2013, 431:496-500.
Book chapters
- Authors: Zufeng Ding, Fenxi Zhang, Yao Dai, JL Mehta, Xianwei Wang*.
- Title: Renin-Angiotensin System: Physiology, Role in Disease and Health Implications
- Chapter: Crosstalk between Renin-Angiotensin System and LOX-1: Implications in Cardiovascular Diseases. Novapublishers. 2013, 119-142.
- ISBN: 978-1-62417-789-7
- Authors: Zufeng Ding, Xianwei Wang, JL Mehta*.
- Title: Biochemical Basis and Therapeutic Implications of Angiogenesis
- Chapter: Microarray, MicroRNA, and Angiogenesis. Springer Link. Volume 6, 2013, 459-477.
- ISBN: 978-1-4614-5856-2
2012
- Ding Z*, Liu S, Yang B, Fan YB, Deng XY. Effect of ox-LDL concentration polarization on human SMCs’ proliferation, cycle, apoptosis and ox-LDL uptake. J Royal Soc Interface, 2012, 9:1233-40.
- Ding Z, Wang X, Khaidakov M, Liu S, Mehta JL. MicroRNA hsa-let-7g targets lectin-like oxidized low-density lipoprotein receptor-1 expression and inhibits apoptosis in human smooth muscle cells. Exp Biol Med. 2012, 237:1093-100.
- Ding Z, Wang X, Khaidakov M, Liu S, Dai Y, Mehta JL. Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells. Biochem Biophys Res Commun. 2012, 426:106-11.
- Wang X, Khaidakov M, Ding Z, Mitra S, Lu J, Dai Y, Mehta JL. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and cardiac fibroblast growth. Hypertension. 2012, 60:1437-42.
- Khaidakov M, Mitra S, Wang X, Ding Z, Bora N, Lyzogubov V, Romeo F, Schichman SA, Mehta JL. Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. PLoS One. 2012, 7:e47421.
- Goyal T, Mitra S, Khaidakov M, Wang X, Singla S, Ding Z, Liu S, Mehta JL. Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis. Curr Atheroscler Rep. 2012 Jan 29. [Epub ahead of print]
- Singla S, Ding Z, Mehta JL. Arterial wall-axon reflex: a potential player in atherosclerosis. Ther Adv Cardiovasc Dis. 2012, 6:181-4.
- Mitra S, Wang X, Khaidakov M, Ding Z, Ayyadevera S, Hearnsberger E, Goyal T, Mehta JL. Aspirin downregulates Angiotensin type 1 receptor transcription implications in capillary formation from endothelial cells. J Cardiovasc Pharmacol. 2012, 60:187-92.
- Wang X, Lu J, Khaidakov M, Mitra S, Ding Z, Goyal T, Mehta JL. Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis. Apoptosis. 2012, 17:908-15.
- Wang X, Lu J, Khaidakov M, Mitra S, Ding Z, Raina S, Goyal T, Mehta JL. Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription. Toxicol Appl Pharmacol. 2012, 259:346-54.
2009-2012
- Ding Z, Fan YB, Deng XY, Zhan F, Kang HY. Effect of swirling flow on the uptakes of native and oxidized LDLs in a straight segment of the rabbit thoracic aorta. Exp Biol Med, 2010, 235:506-513.
- Ding Z, Fan YB, Deng XY, Sun AQ, Kang HY. 3,3’-Dioctadecylindocarbocyanine-low-density lipoprotein uptake and flow patterns in the rabbit aorta–iliac bifurcation under three perfusion flow conditions. Exp Biol Med, 2010, 235:1062-1071.
- Ding Z, Fan YB, Deng XY. Concentration polarization of ox-LDLs: its effect on ox-LDL uptake and apoptosis of the endothelial cells. ASAIO J, 2010, 56:468-474.
- Ding Z, Fan YB, Deng XY. Effect of LDL concentration polarization on the uptake of LDL by human endothelial cells and smooth muscle cells co-cultured. Acta Biochim Biophys Sin, 2009, 41:146-153.