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317-645-8897
About
Professor and Chair
UAMS College of Medicine
Physiology and Cell Biology
UAMS, Little Rock
PUBLICATIONS
Original Peer-Reviewed Articles
- Bellido T, Boland R. In vitro muscle phosphate uptake. Characteristics and action of Vitamin D3 metabolites. In: "Vitamin D: Basic Research and its Clinical Application" (Norman A.W. et al, eds) Walter de Gruyter, Berlin. pp 590-591 (1985)
- Bellido T, Boland R. Phosphate accumulation by muscle in vitro and the influence of Vitamin D3 metabolites. Zeitschrift fur Naturforschung 42c:60-67 (1987)
- Bellido T, Drittanti L., Boland R., de Boland A. The phospholipid and fatty acid composition of skeletal muscle cells during culture in the presence of Vitamin D3metabolites. Biochem Biophys Acta 922:162-169 (1987)
- Bellido T, Boland R. Stimulation of synthesis of myoblast membrane proteins by 25-hydroxy-Vitamin D3. In: "Vitamin D: Basic Research and its Clinical Application" (Norman A.W. et al, eds) Walter de Gruyter, Berlin. pp 421-422 (1988)
- Bellido T. Skeletal muscle phosphate metabolism. Effects and mechanism of action of 25-hydroxy-Vitamin D. Acta Bioquimica Clinica Latinoamericana, 23(1):3-51 (1989)
- Bellido T and Boland R. Stimulation of myoblast membrane protein synthesis by 25-hydroxy-vitamin D3. Zeitschrift fur Naturforschung. Journal of Biosciences, 44c:807-812, 1989.
- Bellido T, Boland R. Stimulation of myoblast membrane protein synthesis by 25-hydroxy-Vitamin D3. Hormone and Metabolic Research 23:113-116 (1991)
- Bellido T., Boland R. Role of second messengers in the stimulation of muscle cell proliferation by 1,25-dihydroxy-Vitamin D3. In: "Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application" (Norman A.W. et al, eds) Walter de Gruyter, Berlin. pp 409-410 (1991)
- Manolagas S.C., Yu X.P., Hustmyer F., Mocharla H., Girasole G., Bellido T., Crabb D. The immunomodulating properties of Vitamin D: Receptors and mechanisms of biologic action. In: "Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application" (Norman A.W. et al, eds) Walter de Gruyter, Berlin. pp 469-477, 1991
- Bellido T., Morelli S., Fernandez L., Boland R. Evidence for the participation of protein kinase C and 3',5'-cyclic AMP-dependent protein kinase in the stimulation of muscle cell proliferation by 1,25-dihydroxy-Vitamin D3. Molecular and Cellular Endocrinology 90:231-238, 1993
- Manolagas S.C., Bellido T., Yu X.P., Girasole G., Mocharla H., Passeri G., Rice N., Crabb D., Jilka R. The role of vitamin D in the immune system and in osteoclastogenesis. In: "Proceedings of IXth International Congress on Endocrinology." Nice, France, 1992.
- Manolagas S.C., Girasole G., Passeri G., Bellido T., Crabb D., Broxmeyer H. and Jilka R. Estrogen loss, cytokines, and osteoclast development. In: "Proceedings of IXth International Congress on Endocrinology." Nice, France, 1992
- Bellido T., Girasole G., Passeri G., Yu X.P., Jilka R., Notides A., Manolagas S.C. Demonstration of estrogen and vitamin D receptors in bone marrow derived murine stromal cells: Upregulation of the estrogen receptor by 1,25(OH)2D3. Endocrinology 133:553-562, 1993
- Manolagas S.C., Jilka R.L., Girasole G., Passeri G., and Bellido T. Estrogens, cytokines, and the pathophysiology of osteoporosis. In: Current Opinion in Endocrinology and Diabetes, vol. 1, Kohler PO (Ed.), Current Science, Philadelphia, pp. 275-281, 1994.
- Pottratz S., Bellido T., Mocharla H., Crabb D., Manolagas S.C. 17ß-estradiol inhibits transcription from the human interleukin-6 promoter. Journal of Clinical Investigation, 93:944-950, 1994.
- Selles J., Bellido T., Boland R. Modulation of calcium uptake in cultured cardiac muscle cells by 1,25-dihydroxyvitamin D3. Journal of Molecular and Cellular Cardiology 26:1593-1599, 1994.
- Bellido T., Jilka R.L., Boyce B., Girasole G., Broxmeyer H., Dalrymple S.A., Murray R., Manolagas S.C. Regulation of interleukin-6 and osteoclastogenesis and bone mass by androgens: The role of the androgen receptor. Journal of Clinical Investigation, 95:2886-2895, 1995.
- Yu X-P, Bellido T., and SC Manolagas. Downregulation of NF- B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. Proceedings of the National Academy of Science USA, 92:10990-10994, 1995.
- Bellido, T., Stahl, N., Farruggella, T., Borba, V., Yancopoulos, G., Manolagas, S.C. Detection of receptors for Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, and Ciliary Neurotrophic Factor in bone marrow stromal/osteoblastic cells. Journal of Clinical Investigation, 97:431-437, 1996.
- Bellido T., Borba, V.Z.C., Roberson, P. and Manolagas S.C. Activation of the JAK/STAT signal transduction pathway by IL-6 type cytokines promotes osteoblast differentiation. Endocrinology, 138:3666-3676, 1997.
- Lin, S.-C., Yamate, T., Taguchi, Y., Borba, V.Z.C., Girasole, G., O’Brien, C. A., Bellido, T., Abe, E., Manolagas, S.C. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. Journal of Clinical Investigation, 100:1980-1990, 1997.
- Jilka, R.L., Weinstein, R.S., Bellido, T., Parfitt, A.M., Manolagas, S.C. Osteoblast programmed cell death (apoptosis): Modulation by growth factors and cytokines. Journal of Bone and Mineral Research, 13:793-802, 1998.
- Bellido, T., O’Brien, C.A., Roberson, P.K., Manolagas, S.C., Transcriptional activation of the p21WAF1,CIP1,SDI1 gene by IL-6 type cytokines: A prerequisite for their prodifferentiating and anti-apoptotic effects on human osteoblastic cells. Journal of Biological Chemistry, 273:21137-21144, 1998.
- Carter C.A., Bellido T. Decrease in tyrosine phosphorylation is associated with F-actin reorganization by retinoic acid in human endometrial adenocarcinoma (RL95-2) cells. Journal of Cellular Physiology, 178:320-332,
- Jilka, R.L., Weinstein, R.S., Bellido, T., Roberson, P., Parfitt, A.M., Manolagas, S.C. Increased bone formation by prevention of osteoblast apoptosis with PTH. Journal of Clinical Investigation, 104:439-446, 1999.
- Plotkin, L.I., Weinstein, R.S., Parfitt, A.M., Roberson, P.K., Manolagas, S.C., Bellido, T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. Journal of Clinical Investigation, 104:1363-1374, 1999. *Featured in the cover and the comments.
- Bellido, T., Huening, M., Raval-Pandya, M., Manolagas, S.C., Christakos, S. Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. Journal of Biological Chemistry 275:26328-26332, 2000.
- O’Brien, C.A., Lin, S.-C., Bellido, T., Manolagas, S.C. Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6 type cytokines. Journal of Cellular Biochemistry 79:532-541, 2000.
- Kousteni, S.*, Bellido, T.*, Plotkin, L.I., O’Brien, C.A., Bodenner, D.L., Han, L., Han, K., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Manolagas, S.C. Non-genotropic, sex non-specific signalling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104:719-730, 2001. * Both considered first authors.
- Mathov, I., Plotkin, L.I., Sgarlata, C.L., Leoni, J., Bellido, T. ERKs and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. Journal of Bone and Mineral Research, 16:2050-2056, 2001.
- Plotkin, L.I., Bellido T. Bisphosphonate-induced, hemichannel-mediated anti-apoptotis through the Src/ERK pathway: a gap junction-independent action of connexin43. Cell Communication and Adhesion, 8(4-6):377-382, 2001.
- Plotkin, L.I., Manolagas, S.C., Bellido T. Transduction of cell survival signals by connexin43 hemichannels. Journal of Biological Chemistry, 277:8648-8657, 2002. *Featured in Nature Reviews Molecular Cell Biology 4, 285-295, 2003.
- Weinstein, R.S., Chen, J-R, Powers, C.C., Stewart, S.A., Landes, R.D., Bellido, T., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. Journal of Clinical Investigation 109:1041-1048, 2002.
- Kousteni, S., Chen, J-R., Bellido, T., Han, , Ali, A.A., O’Brien, C.A., Plotkin, L. I., Fu, Q., Mancino, A.T., Wen, Y., Vertino, C.C. Powers, A.M., Stewart, S.A., Ebert, R., Parfitt, A.M., Weinstein, R.S., Jilka, R.L., Manolagas, S.C. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298:843-846, 2002.
- Ahuja, S.S, Zhao, S, Bellido, T., Plotkin, L.I., Jimenez, F. Bonewald, L.F. CD40 ligand blocks apoptosis induced by tumor necrosis factor a, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line MLO-Y4. Endocrinology 144:1761-1769, 2003.
- Kousteni, S., Han, L., Chen, J-R., Almeida, M., Plotkin, L.I., Bellido, T., Manolagas, S.C. Kinase-mediated regulation of comoon transcription factors accounts for the bone protective effects of sex steroids. Journal of Clinical Investigation 111:1651-1664, 2003. *Featured in the comments.
- Bellido, T., Ali, A.A., Plotkin, L.I., Fu, Q., Gubrij, I., Roberson, P.K., Weinstein, R.S., O’Brien, C.A., Manolagas, S.C., Jilka, R.L. Proteosomal degradation of Runx2 shortens PTH-induced anti-apoptotic signaling in osteoblasts: A putative explanation for why intermittent administration is needed for bone anabolism. Journal of Biological Chemistry 278:50259-50272, 2003. *Featured in Science’s Signal Transduction Knowledge Environment (STKE), Vol 2003, Issue 213, pg 489, December 16, 2003.
- Liu, Y. Porta, A., Peng, X., Gengaro, K., Cunningham, E.B., Li, H., Dominguez, L.A., Bellido, T., Christakos, S. Prevention of glucocorticoid induced apoptosis in osteocytes and osteoblasts by calbindin-D28k. Journal of Bone and Mineral Research 19:479-490, 2004.
- O’Brien, C.A., Jia, D., Plotkin, L.I., Bellido, T., Powers, C.C., Stewart, S.A., Manolagas, S.C., Weinstein, R.S. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145:1835-1841, 2004.
- Chen, J.R., Plotkin, L.I., Aguirre, J.I., Han, L., Jilka, R.L., Kousteni, S., Bellido, T., Manolagas, S.C. Transient versus sustain phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. Journal of Biological Chemistry, 280:4632-4638, 2005.
- Plotkin, L.I., Aguirre, J.I., Kousteni, S., Manolagas, S.C., Bellido, T. Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of ERK activation. Journal of Biological Chemistry, 280:7317-7325, 2005.
- Vertino, A.M., Bula, C.M., Chen, J-R., Almeida, M., Han, L., Bellido, T., Kousteni, S., Norman, A.W., Manolagas, S.C. Nongenotropic, anti-apoptotic signaling of 1,25(OH)2-vitamin D3 and analogs through the ligand binding domain (LBD) of the vitamin D receptor (VDR) in osteoblasts and osteocytes: Mediation by Src, PI3, and JNK kinases. Journal of Biological Chemistry 280:14130-14137, 2005.
- Plotkin, L.I., Mathov, I., Aguirre, J.I., Parfitt, A.M., Manolagas, S.C., Bellido, T. Mechanical stimulation prevents osteocyte apoptosis: Requirement of integrins, Src kinases and ERKs. American Journal of Physiology (Cell Physiology) 289:C633-C643, 2005.
- Bellido, T., Ali, A.A., Gubrij, I., Plotkin, L.I.,O’Brien, C.A., Manolagas, S.C., Jilka, R.L. Chronic elevation of PTH in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146:4577-4583, 2005.
- Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnts prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent as well as independent signaling cascades involving Src/ERK and PI3K/Akt. Journal of Biological Chemistry 280: 41342-41351, 2005.
- Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. Journal of Bone and Mineral Research, 21:605-615, 2006.
- Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone, 39:443-452, 2006.
- Bellido T and Plotkin LI. Prevención de la apoptosis de osteocitos y osteoblastos con bifosfonatos: vía de sobrevida mediada por hemicanales de Cx43 y la activación de quinasas reguladas por señales extracelulares, independientemente de la transcripción génica. Actualizaciones en Osteología (Spanish), 2(3):131-136, 2006.
- Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Molecular and Cellular Biology, 27:1516-1530, 2006.
- Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Letter in response to Windahl et al (Journal of Clinical Investigation, 116:2500-2509, 2006). Journal of Clinical Investigation 116:2834, 2006.
- Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival: Evidence for inside-out signaling leading to anoikis. Journal of Biological Chemistry 282:24120–24130, 2007. *Featured in Science’s Signal Transduction Knowledge Environment (STKE), Vol 2007, Issue 400, pg tw298, August 21, 2007.
- Aguirre JI, Plotkin LI, Gortazar AR, Martin Millan M, O’Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. Journal of Biological Chemistry, 282 25501-25508, 2007.
- Almeida M, Han L, Martin Millan M, Plotkin LI, Stewart SE, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. Journal of Biological Chemistry, 282:27285-27297, 2007.
- Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MJ, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido T, Harris SE, Turner CH. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. Journal of Biological Chemistry, 283:5866-5875, 2008.
- Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T. Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. Journal of Bone and Mineral Research, 23:1712-1721, *Featured in a Commentary.
- O’Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 3(8):32942, 2008. doi:10.1371/journal.pone.0002942
- Plotkin LI, Bivi N, Bellido T. A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice, Bone, 49:122-127, 2011. doi:10.1016/j.bone.2010.08.011
- Rhee Y, Allen MR, Condon K, Lezcano V, Ronda AC, Galli C, Olivos N, Passeri G, O’Brien CA, Bivi N, Plotkin LI, Bellido T. PTH receptor signaling in osteocytes governs periosteal bone formation and intra-cortical remodeling. Journal of Bone and Mineral Research, 26 (5): 1035-1046, 2011. doi:10.1002/jbmr.304
- Gurkan UA, Kishore V, Condon KW, Bellido T, Akkus O. A scaffold-free multicellular three-dimensional in vitro model of osteogenesis. Calcified Tissue International, 88: 388-401, 2011. doi 10.1007/s00223-011-9467-3
- Robling AG, Kedlaya R, Ellis SN, Childress PJ, Bidwell J, Bellido T, Turner CH. Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice. Endocrinology, 152: 2963-2975, 2011.
- Bivi N, Lezcano V, Romanello M, Bellido T, Plotkin, L.I. Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. Journal of Cellular Biochemistry, 112:2920-2930, 2011. doi:10.1002/jcb.23208.
- Rhee Y, Farrow E, Bivi N, Lezcano V, Plotkin LI, White KE, Bellido T. Parathyroid hormone controls the endocrine and auto/paracrine function of osteocytes by upregulating the expression of fibroblast growth factor-23. Bone, 49:636-643, 2011. doi:10.1016/j.bone.2011.06.025
- Bivi N, Condon K, Allen MR, Farlow N, Passeri G, Rhee Y, Bellido T, Plotkin LI. Cell autonomous requirement of Cx43 for osteocyte viability: consequences for endocortical resorption and periosteal bone formation. Journal of Bone and Mineral Research, 27:374-379, 2012. doi:10.1002/jbmr.548
- Tu X, Rhee Y, Condon K, Bivi N, Allen MR, Dwyer D, Stolina M, Turner CH, Robling AG, Plotkin LI, Bellido T. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone, 50:209-217, 2012. (Most cited paper published in Bone in 2012-2013)
- Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T. Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine
osteocytes is not sufficient to increase hematopoietic stem cells. Blood, 119:2489-2499, 2012.
- Turek J, Ebetino FH, Lundy MW, Sun S, Kashemirov BA, McKenna CE, Gallant MA, Plotkin LI, Bellido T, Duan X, Triffitt JT, Russell RGG, Burr DB, Allen MR. Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits. Calcified Tissue International, 90:202-210, 2012. doi:10.1007/s00223-012-9570-0
- Lezcano V, Bellido T, Plotkin LI, Boland R, Morelli S. Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways. Archives of Biochemistry and Biophysics, 518:95-102, 2012. doi:10.1016/j.abb.2011.12.022
- Rodriguez de Gortazar A, Martin-Millan M, Bravo B, Plotkin LI, Bellido T. Crosstalk between caveolin-1/ERKs and β-catenin survival pathways in osteocyte mechanotransduction. Journal of Biological Chemistry, 288:8168-8175, 2013
- Bivi N, Pacheco-Costa R, Brun LR, Murphy TR, Farlow NR, Robling AG, Bellido T, Plotkin LI. Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice. Journal of Orthopedic Research, 31:1075-1081, 2013; DOI:10.1002/jor.22341.
- Rhee Y, Lee E-Y, Lezcano V, Ronda AC, Allen MR, Plotkin LI, Bellido T. Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes. Journal of Biological Chemistry, 288:29809-29820, 2013; doi: 10.1074/jbc.M113.485938.
- Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia T-H, Zhen G, Cao X, Ling H, Dechow PC, Bellido T, Ledbetter SR, Schiavi SC. Anti-TGF-β Antibody Attenuates High-turnover Bone Disease Associated with CKD. Journal of Bone and Mineral Research, 29:1141-1157, 2014.
- Lezcano V, Bellido T, Plotkin LI, Boland RL, Morelli S. Osteoblastic protein tyrosine phosphatases inhibition and connexin43 phosphorylation by alendronate. Experimental Cell Research, 324:30-39, 2014.
- Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka G, Mu J, Chen DZ, Srour EF, Chitteti BR, HogenEsch H, Tu X, Bellido T, Boswell S, Manshouri T, Verstovsek S, Yoder M, Kapur R, Cardoso AA, Carlesso N. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in a NF-κB dependent manner. Cell Stem Cell, 15:51-65, 2014.
- Ben-Awadh A, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology, 155:2797-2809, 2014.
- Artsi A, Cohen-Kfir E, Gurt I, Shahar R, Bajayo A, Kalish N, Gabet Y, Bellido T, Dresner-Pollak R. The sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. Endocrinology, 155:3508-3515, 2014.
- Sato AY, Tu X, McAndrews KA, Plotkin LI, Bellido T. Prevention of Glucocorticoid Induced-Apoptosis of Osteoblasts and Osteocytes by Protecting against Endoplasmic Reticulum (ER) Stress in vitro and in vivo in Female Mice. Bone, 73: 60-68, 2015
- Tu X,* Delgado-Calle J,* Condon K, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr D, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/βcatenin signaling in bone. Proceedings of National Academy of Sciences, 112 (5) E478-E486, 2015. [Epub ahead of print] (Highlighted in Nature Reviews Endocrinology; and in Nature Reviews Rheumatology) *Both first authors
- Wright L, Buijs J, Kim H-S, Coats L, Scheidler A, John S, She Y, Murthy S, Ma N, Chin-Sinex H, Bellido T, Bateman T, Mendonca M, Mohammad K, Guise T. Single-limb irradiation induces local and systemic bone loss in a murine model. Journal of Bone and Mineral Research, 30 (7): 1268-1279, 2015, doi: 10.1002/jbmr.2458.
- Niziolek PJ, MacDonald BT, Kedlaya R, Zhang M, Bellido T, He X, Warman ML, Robling AG. High-bone-mass causing mutant LRP5 receptors are resistant to endogenous inhibitors in vivo. J Bone Miner Res. 2015 Mar 24. doi: 10.1002/jbmr.2514.
- Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T. Inhibition of osteocyte apoptosis prevents the increase in osteocytic RANKL but it does not stop bone resorption or the loss of bone induced by unloading. J Biol Chem. Jun 17. pii: jbc.M115.642090, 2015.
- Pacheco-Costa R, Davis HM, Sorenson C, Hon MC, Hassan I, Reginato RD, Allen MR, Bellido T, Plotkin LI. Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain. Bone 2015, 10.1016/j.bone.2015.09.011
- Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch signaling and osteocyte-derived factors drive tumor cell proliferation and bone destruction in multiple myeloma. Cancer Research, 2016, DOI: 10.1158/0008-5472.CAN-15-1703.
- Clinkenbeard EL, Cass TA, Ni P, Hum JM, Bellido T, Allen MR, White KE. Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia. J Bone Miner Res, 31(6): 1247-1257, 2016.
- Plotkin LI, Gortazar AR, Bellido T. β-arrestin/connexin 43 complex anchors ERKs outside the nucleus: a pre-requisite for bisphosphonate anti-apoptotic effect mediated by Cx43/ERK in osteocytes. Actualizaciones en Osteología 12:11-20, 2016.
- Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection from Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. Journal of Bone and Mineral Research, 31(10): 1791-1802, 2016
- Pellegrini GG, Morales CC, Wallace TC, Plotkin LI, Bellido T. Avenanthramides prevent osteoblast and osteocyte apoptosis and induce osteoclast apoptosis in an Nrf2-independent manner. Nutrients, 2016 8, 423-427; doi:10.3390/nu8070423
- Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T. PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading. Journal of Bone and Mineral Research 2017 Mar;32(3):486-497. doi: 10.1002/jbmr.3007. Epub 2016 Oct 24.
- Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini G, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. Journal of Bone and Mineral Research, 2017 Mar;32(3):522-535. doi: 10.1002/jbmr.3011. Epub 2016 Oct 27.
- Sato AY, Richardson D, Cregor M, Davis HM, Au ED, McAndrews K, Zimmers TA, Organ JM, Peacock M, Plotkin LI, Bellido T. Glucocorticois induce bone and muscle atrophy by tissue-specific mechanisms upstream of E3 ubiquitin ligases. Endocrinology, 2017 Mar 1;158(3):664-677. doi: 10.1210/en.2016-1779.
- Pellegrini GG, Cregor M, McAndrews K, Morales CC, Doyle McCabe L, McCabe GP, Peacock M, Burr D, Weaver C, Bellido T. Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. PLoS ONE, 2017 Feb 2;12(2):e0171161. doi: 10.1371/journal.pone.0171161. eCollection 2017.
- Davis HM, Pacheco-Costa R, Atkinson EG, Brun LR, Gortazar AR, Harris J, Hiasa M, Bolarinwa SA, Yoneda T, Ivan M, Bruzzaniti A, Bellido T, Plotkin LI. Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. Aging Cell (2017). doi: 10.1111/acel.12586
- Komaba H, Kaludjerovic J, Hu DJ, Nagano K, K Amano, Ide N, Sato T, Densmore MJ, Hanai J, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho in osteocytes regulates bone formation: the role in bone physiology and renal osteodystrophy. Kidney International 2017 Apr 8. pii: S0085-2538(17)30120-5. doi: 10.1016/j.kint.2017.02.014.
- Long F, He G, Shi Y, Lim J, Bellido T, Ni J. Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth. Bone Research 2017 Jun 6;5:17016. doi: 10.1038/boneres. 2017.16.
- Delgado-Calle J, Anderson J, Cregor M, Condon K, Kuhstoss S, Plotkin LI, Bellido T,* and Roodman GD*. Genetic Deletion of Sost or Pharmacological Inhibition of Sclerostin Prevent Multiple Myeloma-induced Bone Disease without Affecting Tumor Growth. Leukemia doi: 10.1038/leu.2017.152, 2017. * Corresponding authors
- Kegelman CD, Mason DE, Dawahare JH, Horan D, Vigil GD, Howard SS, Robling AR, Bellido T, Boerckel JD. Skeletal cell YAP and TAZ combinatorially promote bone development. FASEB J. 2018 May;32(5):2706-2721. doi: 10.1096/fj.201700872R. Epub 2018 Jan 10.
- Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 32(5):2878-2890. doi: 10.1096/fj.201700919RRR. Epub 2018 Jan 17.
- Davis HM, Aref MW, Aguilar-Perez A, Pacheco-Costa R, Allen K, Valdez S, Herrera C, Atkinson EG, Mohammad A, Lopez D, Harris MA, Harris SE, Allen MR, Bellido T, Plotkin LI. Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice. Journal of Bone and Mineral Research-Plus 2018 2(4):206-216. doi: 10.1002/jbm4.10035. Epub 2018 Jan 18.
- Pacheco-Costa R, Davis HM, Atkinson EG, Dilley JE, Byiringiro I, Aref MW, Allen MR, Bellido T, Plotkin LI. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 114:22-31. doi: 10.1016/j.bone.2018.06.002. Epub 2018 Jun 5.
- Alam I, Oakes D, Reilly A, Billingsley C, Sbeta S, Gerard-O’Riley R, Acton D, Sato AY, Bellido T, Econs M. Overexpression of WNT16 does not rescue cortical bone loss due to glucocorticoid treatment in mice. Journal of Bone and Mineral Research-Plus DOI: 1002/jbm4.10084; JBMR1Plus, 3 (2), 2019, pp 1–14
- Li J-Y, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R. IL-17 receptor signaling in osteoblastic/osteocytes mediates PTH-induced bone loss and enhances osteocytic RANKL production. Journal of Bone and Mineral Research. 2019 34(2):349-360 DOI: 10.1002/jbmr.3600 (in press). 30399207
- Rauner M, Baschant U, Roetto A, Pellegrino RM, Salbach-Hirsch J, Weidner H, Rother S, Hintze V, Campbel G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett DJH, Williams GR, Platzbecker U, Hofbauer LC. Transferrin receptor 2 is a novel BMP receptor that regulates bone formation and ossification. Nature Metabolism, 2019 Jan;1(1):111-124. doi: 10.1038/s42255-018-0005-8. Epub 2019 Jan 7.
- Wu Y, Yuan X, Perez KC, Hyman S, Wang L, Pellegrini G, Salmon B, Bellido T, Helms JA. Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis. Bone, 2018 Oct 25. pii: S8756-3282(18)30403-4. doi: 10.1016/j.bone.2018.10.023. [Epub ahead of print]
- Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long C, Schlüter H, Kwiatkowski M, Saini V, Divieti Pajevic P, Bellido T, van Wijnen A, Mohammad K, Guise T, Taipaleenmäki H, and Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nature Communications, 2019, Mar 22;10(1):1354. doi: 10.1038/s41467-019-08778-x.
- Sato AY, Cregor M, McAndrews K, Li T, Condon KW, Plotkin LI, Bellido T. Glucocorticoid-induced bone fragility is prevented in female mice by blocking Pyk2/anoikis signaling. Endocrinology, 2019, Jul 1;160(7):1659-1673. doi: 10.1210/en.2019-00237. PMID: 31081900 Free PMC article.
- Davis HM, Deosthale PJ, Pacheco-Costa R, Essex AL, Atkinson EG, Aref MW, Dilley JE, Bellido T, Ivan M, Allen M, Plotkin LI. Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover. The FEBS Journal, 2020 Mar;287(5):941-963. doi: 10.1111/febs.15066. Epub 2019 Oct 8. PMID: 31532878
- Kegelman CD, Coulombe JC, Jordan KM, Horan DJ, Qin L, Robling AG, Ferguson VL, Bellido TM, Boerckel JD. YAP and TAZ mediate osteocyte perilacunar/canalicular remodeling. Journal of Bone and Mineral Research, 2020 Jan;35(1):196-210. doi: 10.1002/jbmr.3876. Epub 2019 Oct 14.
- Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling A. 2019. Lrp4 mediates bone homeostasis and mechanotransduction through interaction with sclerostin in vivo. iScience 20 (205-215). https://doi.org/10.1016/j.isci.2019.09.023. Epub 2019 Sept 18.
- Zhao Y, Yuan X, Bellido T, Helms JA. A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion. J Endod. 2019 Nov;45(11):1357-1364.e1. doi: 10.1016/j.joen.2019.07.014. Epub 2019 Sep 12. PMID: 31522810
- Corry KA, Zhou H, Brustovetsky T, Himes ER, Bivi N, Horn MR, Kitase Y, Wallace JM, Bellido T, Brustovetsky N, Li J. Stat3 in osteocytes mediates osteogenic response to loading. Bone Rep. 2019 Jul 29;11:100218. doi: 10.1016/j.bonr.2019.100218. eCollection 2019 Dec. PMID: 31440530 Free PMC article.
- Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T. Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. Oncotarget. 2019 Apr 12;10(28):2709-2721. doi: 10.18632/oncotarget.26831. eCollection 2019 Apr 12. PMID: 31105871 Free PMC article.
Invited Reviews, Commentaries, Perspectives
- Manolagas S.C., Jilka R., Girasole G., Passeri G., Bellido T. Estrogen, cytokines, and the control of osteoclast formation and bone resorption in-vitro and in-vivo. Osteoporosis International, 3(Suppl. 1):S114-116 (1991)
- Manolagas S.C., Yu X.P., Girasole G., Bellido T. Vitamin D and the hematolymphopoietic tissue: A 1994 update. Seminars in Nephrology, 14:129-143, 1994.
- Manolagas S.C., Bellido T., Jilka R.L. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. International Journal of Immunopharmacology, 17:109-116, 1995.
- Manolagas S.C., Bellido T., Jilka R.L. Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of osteoporosis. Ciba Foundation Simposium, 191: 187-196, 1995.
- Manolagas S.C., Kousteni S., Chen J.R., Schuller M., Plotkin L.I., Bellido T. Kinase-mediated transcription, activators of non-genotropic estrogen like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma. Kidney International, 91:S41-49, 2004.
- Bellido T. Osteocyte control of bone formation via Sost/sclerostin. Musculoskelet. Neuronal Interact., 6:360-3, 2006.
- Bellido T. Downregulation of Sost/Sclerostin by PTH: A novel mechanism of hormonal control of bone formation mediated by osteocytes. Musculoskelet. Neuronal Interact., 6:358-9, 2006.
- Robling AG, Bellido T., Turner CH. Mechanical stimulation in vivo reduces osteocyte expression of sclerostin. Musculoskelet. Neuronal Interact., 6:354, 2006.
- Bellido T. The osteocyte: The “third” cell of bone gets to center stage (Report from the 28th annual meeting of the American Society for Bone and Mineral Research). BoneKEy-Osteovision, November 3, 2006 (11) 14-50.
- Bellido T. Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness. BoneKEy-Osteovision, September 2007, 4 (9):252-256.
- Bilezikian JP, Matsumoto T, Bellido T, Khosla S, Martin J, Recker RR, Heaney R, Seeman E, Papapoulos S, Goldring S. Targeting bone remodeling for the treatment of osteoporosis: Summary of the Proceedings of an ASBMR workshop. Journal of Bone and Mineral Research, 24:373-385, 2009
- Bellido T. Osteocyte death: A beacon for targeted remodeling. Actualizationes en Osteologia (Spanish), 5(1):21-24, 2009.
- Turner CH, Warden SJ, Bellido T, Plotkin LI, Kumar N, Jasiuk I, Danzig J, Robling AG. Mechanobiology of the skeleton. Science Signaling, 2(68):pt3, 2009
- Bellido T. Antagonistic interplay between mechanical forces and glucocorticoids: a tale of kinases. Journal of Cell Biochemistry, 111:1-6, 2010.
- Bellido T, Plotkin LI. Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability, Bone, 49:50-55, 2011
- Khosla S, Bellido T, Drezner MK, Gordon CM, Harris TB, Kiel DP, Kream BE, Leboff MS, Lian JB, Peterson CA, Rosen CJ, Williams JP, Winer KK, Sherman SS. Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop. Journal of Bone and Mineral Research, 26: 2565-2578, 2011
- Bellido T, Saini V, Divieti Pajevic P. Effects of PTH on osteocyte function. Invited review, Bone, 54: 250-257, 2013
- Plotkin LI, Bellido T. Beyond gap junctions: Connexin43 and bone cell signaling. Invited review, Bone, 52: 157-166, 2013
- Bellido T. Osteocytes and their role in bone remodeling. Actualizaciones en Osteologia (Spanish), 9: 56-64, 2013
- Bellido T. Osteocyte-driven bone remodeling. Calcified Tissue International, 94:25-34, 2014. (One of the 11th most cited papers in CTI 2014-2015)
- Plotkin LI, Bellido T. Comment on Osteocytes: Masters Orchestrators of Bone. Calcified Tissue International, 95:382-383, 2014
- Delgado Calle J, Bellido T, Roodman GD. Role of osteocytes in multiple myeloma. Current opinion in supportive and palliative care. Bone and hematopological problems. Lippincott, Williams & Wilkins, 8:407-413, 2014.
- Delgado Calle J, Bellido T. Osteocytes and skeletal pathophysiology. Current Molecular Biology Reports, 1(4): 157-167, 2015
- Plotkin LI, Bellido T. From inside your bones: Osteocytic signalling pathways as therapeutic targets for bone fragility. Nature Reviews Endocrinology, 12 (10):593-605, 2016
- Delgado Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone, 96: 29-37, 2017
- Ayus JC, Bellido T, Negri AL. Hyponatremia and fractures: should hyponatremia be further studies as a potential biochemical risk factor to be included in FRAX algorithms? Osteoporosis International, 28 (5): 1543-1548, 2017
- Delgado Calle J, Bellido T. New insights into the local and systemic functions of sclerostin: regulation of quiescent bone lining cells and beige adipogenesis in peripheral fat depots. Journal of Bone and Mineral Research, 32 (5): 889-891, 2017
- Sato AY, Peacock M, Bellido T. Glucocorticoid excess in bone and muscle. Clinical Reviews in Bone and Mineral Metabolism 16 (1):33-47, 2018.
- Ward LM, Kinnett K, Bonewald L; Parent Project Muscular Dystrophy Bone Health Workshop Collaborators (Bellido T). Proceedings of a Parent Project Muscular Dystrophy Bone Health Workshop: Morbidity due to osteoporosis in DMD: The Path Forward May 12-13, 2016, Bethesda, Maryland, USA. Neuromuscul Disord. 2018 Jan;28(1):64-76. doi: 10.1016/j.nmd.2017.05.012. Epub 2017 May 15.
- Pagnotti GM, Marino S, Petrusca DN, Bellido T, Roodman GD, Delgado-Calle J. Role of Osteoblasts in Cancer Induced Bone Disease. Bone Enciclopedia, 2019, doi.org/10.1016/B978-0-12-801238-3.11254-1
- Delgado-Calle J, Bellido T. Ex Vivo Organ Cultures as Models to Study Bone Biology. JBMR Plus 2020, ID: JBM410345, DOI: 10.1002/jbm4.10345
Book Chapters
- Manolagas SC, Jilka RL, Bellido T, O'Brien CA, Parfitt AM. Interleukin-6 type cytokines and their receptors. Principles of Bone Biology (J.P. Bilezikian, L.G. Raisz and G.A. Rodan, Editors), 701-713. 1996.
- Boyce BF, Xing L, Jilka RL, Bellido T, Weinstein RS, Parfitt AM, Manolagas SC. Apoptosis in bone cells. Principles of Bone Biology, second edition (J.P. Bilezikian, L.G. Raisz and G.A. Rodan, Editors), Chapter 10, 151-168, 2002.
- Bellido T and Plotkin LI. Detection of apoptosis of bone cells in vitro (Chapter 4). Methods in Molecular Biology, Osteoporosis Methods and Protocols. (J. Westendorf, Editor), Humana Press, USA, 51-75, 2008.
- Jilka RL, Bellido T, Almeida A, Plotkin LI, O’Brien CA, Weinstein RS, Manolagas SC. Apoptosis of bone cells. Principles of Bone Biology, third edition (J.P. Bilezikian, L.G. Raisz and G.A. Rodan, Editors), Academic Press, 237-261, 2008
- Burr DB, Bellido T, White K. Bone structure and function (Chapter 9). Rheumatology, fifth edition (M.C. Hochberg, A.J. Silman, J.S. Smolen, M.E. Weinblatt, M.H. Weisman, Editors) Elsevier, 67-81, 2011.
- Bellido T, Plotkin LI, Bruzzaniti A. Bone cells (Chapter 2). Basic and Applied Bone Biology. First edition (D Burr and M Allen, Editors) Elsevier, 2014.
- Bellido T, Hill K. Hormonal effects on bone cells (Chapter 15). Basic and Applied Bone Biology. First edition (D Burr and M Allen, Editors) Elsevier, 2014.
- Burr DB, Bellido T, White K. Bone structure and function (Chapter 6). Rheumatology, sixth edition (M.C. Hochberg, A.J. Silman, J.S. Smolen, M.E. Weinblatt, M.H. Weisman, Editors) Elsevier, 2014.
- Burr DB, Bellido T, White K. Bone structure and function (Chapter 6). Rheumatology, seventh edition (M.C. Hochberg, A.J. Silman, J.S. Smolen, M.E. Weinblatt, M.H. Weisman, Editors) Elsevier, 2016.
- Bellido T, Divieti Pajevic, Bonewald. Osteocyte biology (Chapter 2). Genetics of Bone Biology and Skeletal Disease, 2nd Edition, 2017
- Bellido T and Delgado-Calle J. Basic Aspects of Osteocyte Function (Chapter). Osteoporosis: Pathophysiology and Clinical Management (in press), 2018